Qihua Xiong (Inventor), Cuong Cao (Inventor), Jun Zhang (Inventor)

Research output: Patent


The present invention relates to a logic gate, comprising a metamaterial surface enhanced Raman scattering (MetaSERS) sensor, comprising (a) alphabetical metamaterials in the form of split ring resonators operating in the wavelength range of from 560 to 2200 nm; and (b) a guanine (G) and thymine (T)-rich oligonucleotide that can, upon presence of potassium cations (K+), fold into a G-quadruplex structure, and in presence of Hg2+, form a T-Hg2+-T hairpin complex that inhibits or disrupts the G-quadruplex structure formed in presence of K+, as well as methods of operating and using such a logic gate.
Original languageEnglish
Patent number20160131585
IPCG01N21/65; G01N33/20
Publication statusPublished - 12 May 2016

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