Methylation status of oestrogen receptor-a-gene promoter sequences in human ovarian epithelial cell lines.

John Nelson, I Hickey, A.M. O'Doherty, Stewart Church, Hilary Russell

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

We have determined the methylation status of the CpG island of the oestrogen receptor gene in seven human ovarian cell lines. Cell lines expressing oestrogen receptor showed no evidence of hypermethylation. In three of four cell lines that produced no detectable oestrogen receptor protein, hypermethylation was observed at the NotI site of the CpG island. These results indicate that aberrant hypermethylation may be responsible for a significant proportion of epithelial ovarian tumours in which oestrogen receptor expression is lost.
Original languageEnglish
Pages (from-to)282-284
Number of pages3
JournalBritish Journal of Cancer
Volume86(2)
Issue number2
DOIs
Publication statusPublished - 21 Jan 2002

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Fingerprint Dive into the research topics of 'Methylation status of oestrogen receptor-a-gene promoter sequences in human ovarian epithelial cell lines.'. Together they form a unique fingerprint.

  • Cite this