MIC-1 (a multifunctional modulator of dendritic cell phenotype and function) is produced by decidual stromal cells and trophoblasts

S E Segerer, L Rieger, M Kapp, Y Dombrowski, N Müller, J Dietl, U Kämmerer

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)

Abstract

Macrophage inhibitory cytokine-1 (MIC-1) is a multifunctional cytokine produced in high amounts by placental tissue. Inhibiting trophoblast invasion and suppressing inflammation through inhibition of macrophage activation, MIC-1 is thought to provide pleiotropic functions in the establishment and maintenance of pregnancy. So far, little is known about the decidual cell subsets producing MIC-1 and the effect of this cytokine on dendritic cells (DCs), which are known to play a distinct role in the development of pro-fetal tolerance in pregnancy.
Original languageEnglish
Pages (from-to)200-9
Number of pages10
JournalHuman reproduction (Oxford, England)
Volume27
Issue number1
DOIs
Publication statusPublished - Jan 2012

Keywords

  • Antigens, CD
  • Antigens, CD86
  • Cell Movement
  • Cell Proliferation
  • Decidua
  • Female
  • Flow Cytometry
  • Growth Differentiation Factor 15
  • Humans
  • Immunoglobulins
  • Indoleamine-Pyrrole 2,3,-Dioxygenase
  • Inflammation
  • Interleukin-2 Receptor alpha Subunit
  • Membrane Glycoproteins
  • Monocytes
  • Phenotype
  • Stromal Cells
  • Transforming Growth Factor beta
  • Trophoblasts

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