MIC-1 (a multifunctional modulator of dendritic cell phenotype and function) is produced by decidual stromal cells and trophoblasts

S E Segerer; L Rieger; M Kapp; Y Dombrowski; N Müller; J Dietl; U Kämmerer

doi:10.1093/humrep/der358

MIC-1 (a multifunctional modulator of dendritic cell phenotype and function) is produced by decidual stromal cells and trophoblasts

S E Segerer, L Rieger, M Kapp, Y Dombrowski, N Müller, J Dietl, U Kämmerer

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

Macrophage inhibitory cytokine-1 (MIC-1) is a multifunctional cytokine produced in high amounts by placental tissue. Inhibiting trophoblast invasion and suppressing inflammation through inhibition of macrophage activation, MIC-1 is thought to provide pleiotropic functions in the establishment and maintenance of pregnancy. So far, little is known about the decidual cell subsets producing MIC-1 and the effect of this cytokine on dendritic cells (DCs), which are known to play a distinct role in the development of pro-fetal tolerance in pregnancy.

Original language	English
Pages (from-to)	200-9
Number of pages	10
Journal	Human reproduction (Oxford, England)
Volume	27
Issue number	1
DOIs	https://doi.org/10.1093/humrep/der358
Publication status	Published - Jan 2012

Keywords

Antigens, CD
Antigens, CD86
Cell Movement
Cell Proliferation
Decidua
Female
Flow Cytometry
Growth Differentiation Factor 15
Humans
Immunoglobulins
Indoleamine-Pyrrole 2,3,-Dioxygenase
Inflammation
Interleukin-2 Receptor alpha Subunit
Membrane Glycoproteins
Monocytes
Phenotype
Stromal Cells
Transforming Growth Factor beta
Trophoblasts

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10.1093/humrep/der358

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title = "MIC-1 (a multifunctional modulator of dendritic cell phenotype and function) is produced by decidual stromal cells and trophoblasts",

abstract = "Macrophage inhibitory cytokine-1 (MIC-1) is a multifunctional cytokine produced in high amounts by placental tissue. Inhibiting trophoblast invasion and suppressing inflammation through inhibition of macrophage activation, MIC-1 is thought to provide pleiotropic functions in the establishment and maintenance of pregnancy. So far, little is known about the decidual cell subsets producing MIC-1 and the effect of this cytokine on dendritic cells (DCs), which are known to play a distinct role in the development of pro-fetal tolerance in pregnancy.",

keywords = "Antigens, CD, Antigens, CD86, Cell Movement, Cell Proliferation, Decidua, Female, Flow Cytometry, Growth Differentiation Factor 15, Humans, Immunoglobulins, Indoleamine-Pyrrole 2,3,-Dioxygenase, Inflammation, Interleukin-2 Receptor alpha Subunit, Membrane Glycoproteins, Monocytes, Phenotype, Stromal Cells, Transforming Growth Factor beta, Trophoblasts",

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year = "2012",

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doi = "10.1093/humrep/der358",

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T1 - MIC-1 (a multifunctional modulator of dendritic cell phenotype and function) is produced by decidual stromal cells and trophoblasts

AU - Segerer, S E

AU - Rieger, L

AU - Kapp, M

AU - Dombrowski, Y

AU - Müller, N

AU - Dietl, J

AU - Kämmerer, U

PY - 2012/1

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AB - Macrophage inhibitory cytokine-1 (MIC-1) is a multifunctional cytokine produced in high amounts by placental tissue. Inhibiting trophoblast invasion and suppressing inflammation through inhibition of macrophage activation, MIC-1 is thought to provide pleiotropic functions in the establishment and maintenance of pregnancy. So far, little is known about the decidual cell subsets producing MIC-1 and the effect of this cytokine on dendritic cells (DCs), which are known to play a distinct role in the development of pro-fetal tolerance in pregnancy.

KW - Antigens, CD

KW - Antigens, CD86

KW - Cell Movement

KW - Cell Proliferation

KW - Decidua

KW - Female

KW - Flow Cytometry

KW - Growth Differentiation Factor 15

KW - Humans

KW - Immunoglobulins

KW - Indoleamine-Pyrrole 2,3,-Dioxygenase

KW - Inflammation

KW - Interleukin-2 Receptor alpha Subunit

KW - Membrane Glycoproteins

KW - Monocytes

KW - Phenotype

KW - Stromal Cells

KW - Transforming Growth Factor beta

KW - Trophoblasts

U2 - 10.1093/humrep/der358

DO - 10.1093/humrep/der358

M3 - Article

C2 - 22064648

VL - 27

SP - 200

EP - 209

JO - Human reproduction

JF - Human reproduction

SN - 0268-1161

IS - 1

ER -

MIC-1 (a multifunctional modulator of dendritic cell phenotype and function) is produced by decidual stromal cells and trophoblasts

Abstract

Keywords

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