Abstract
Macrophage inhibitory cytokine-1 (MIC-1) is a multifunctional cytokine produced in high amounts by placental tissue. Inhibiting trophoblast invasion and suppressing inflammation through inhibition of macrophage activation, MIC-1 is thought to provide pleiotropic functions in the establishment and maintenance of pregnancy. So far, little is known about the decidual cell subsets producing MIC-1 and the effect of this cytokine on dendritic cells (DCs), which are known to play a distinct role in the development of pro-fetal tolerance in pregnancy.
Original language | English |
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Pages (from-to) | 200-9 |
Number of pages | 10 |
Journal | Human reproduction (Oxford, England) |
Volume | 27 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2012 |
Keywords
- Antigens, CD
- Antigens, CD86
- Cell Movement
- Cell Proliferation
- Decidua
- Female
- Flow Cytometry
- Growth Differentiation Factor 15
- Humans
- Immunoglobulins
- Indoleamine-Pyrrole 2,3,-Dioxygenase
- Inflammation
- Interleukin-2 Receptor alpha Subunit
- Membrane Glycoproteins
- Monocytes
- Phenotype
- Stromal Cells
- Transforming Growth Factor beta
- Trophoblasts