Microbial Regulation of Gastrointestinal Immunity in Health and Disease

Sheila Patrick; Rebecca Ingram; Thamarai Schneiders; Denise Fitzgerald

Microbial Regulation of Gastrointestinal Immunity in Health and Disease

Sheila Patrick, Rebecca Ingram, Thamarai Schneiders, Denise Fitzgerald

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

Abstract

The gastrointestinal (GI) tract represents the front line of microbial-host interaction by virtue of its immense surface area and constant microbial supply from ingested food. The gastrointestinal immune system shapes the communities of microbes throughout the GI tract, and in turn, the microbiota provide metabolites and other cues to support the development and normal function of the immune system. Emerging research shows that this influence on the immune system encompasses both innate and adaptive immunity and extends beyond the gut to anatomical sites throughout the body. This chapter presents an overview of the microbiology and immunology of the GI tract, examines microbial population dynamics revealed by studies such as the Human Microbiome Project and discusses the potential impact of emerging antimicrobial resistance to the microbiota and human health.

Original language	English
Title of host publication	Neuro-Immuno-Gastroenterology
Editors	Cris Constantinescu, Razvan Arsenescu, Violeta Arsenescu
Publisher	Springer
Pages	39-52
Number of pages	14
ISBN (Print)	978-3-319-28609-9
Publication status	Published - 25 May 2016

Bibliographical note

Author contribution: Senior author, coordinated writing of co-authors, wrote content and liaised with editor.

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title = "Microbial Regulation of Gastrointestinal Immunity in Health and Disease",

abstract = "The gastrointestinal (GI) tract represents the front line of microbial-host interaction by virtue of its immense surface area and constant microbial supply from ingested food. The gastrointestinal immune system shapes the communities of microbes throughout the GI tract, and in turn, the microbiota provide metabolites and other cues to support the development and normal function of the immune system. Emerging research shows that this influence on the immune system encompasses both innate and adaptive immunity and extends beyond the gut to anatomical sites throughout the body. This chapter presents an overview of the microbiology and immunology of the GI tract, examines microbial population dynamics revealed by studies such as the Human Microbiome Project and discusses the potential impact of emerging antimicrobial resistance to the microbiota and human health.",

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Microbial Regulation of Gastrointestinal Immunity in Health and Disease. / Patrick, Sheila ; Ingram, Rebecca; Schneiders, Thamarai; Fitzgerald, Denise.

Neuro-Immuno-Gastroenterology. ed. / Cris Constantinescu; Razvan Arsenescu; Violeta Arsenescu. Springer, 2016. p. 39-52.

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

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T1 - Microbial Regulation of Gastrointestinal Immunity in Health and Disease

AU - Patrick, Sheila

AU - Ingram, Rebecca

AU - Schneiders, Thamarai

AU - Fitzgerald, Denise

N1 - Author contribution: Senior author, coordinated writing of co-authors, wrote content and liaised with editor.

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Y1 - 2016/5/25

N2 - The gastrointestinal (GI) tract represents the front line of microbial-host interaction by virtue of its immense surface area and constant microbial supply from ingested food. The gastrointestinal immune system shapes the communities of microbes throughout the GI tract, and in turn, the microbiota provide metabolites and other cues to support the development and normal function of the immune system. Emerging research shows that this influence on the immune system encompasses both innate and adaptive immunity and extends beyond the gut to anatomical sites throughout the body. This chapter presents an overview of the microbiology and immunology of the GI tract, examines microbial population dynamics revealed by studies such as the Human Microbiome Project and discusses the potential impact of emerging antimicrobial resistance to the microbiota and human health.

AB - The gastrointestinal (GI) tract represents the front line of microbial-host interaction by virtue of its immense surface area and constant microbial supply from ingested food. The gastrointestinal immune system shapes the communities of microbes throughout the GI tract, and in turn, the microbiota provide metabolites and other cues to support the development and normal function of the immune system. Emerging research shows that this influence on the immune system encompasses both innate and adaptive immunity and extends beyond the gut to anatomical sites throughout the body. This chapter presents an overview of the microbiology and immunology of the GI tract, examines microbial population dynamics revealed by studies such as the Human Microbiome Project and discusses the potential impact of emerging antimicrobial resistance to the microbiota and human health.

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BT - Neuro-Immuno-Gastroenterology

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A2 - Arsenescu, Razvan

A2 - Arsenescu, Violeta

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