Microbubble-sonosensitiser conjugates as therapeutics in sonodynamic therapy

Nikolitsa Nomikou, Colin Fowley, Niall M Byrne, Bridgeen McCaughan, Anthony P McHale, John F Callan

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)


A Rose Bengal sonosensitiser has been covalently attached to a lipid microbubble and the resulting conjugate shown to produce higher levels of singlet oxygen, enhanced cytotoxicity in a cancer cell line and a greater reduction in tumour growth than the sonosensitiser alone.

Original languageEnglish
Pages (from-to)8332-4
Number of pages3
JournalChemical Communications
Issue number67
Publication statusPublished - 28 Aug 2012
Externally publishedYes


  • Cell Line, Tumor
  • Drug Delivery Systems
  • Humans
  • Microbubbles/therapeutic use
  • Models, Biological
  • Molecular Structure
  • Neoplasms/therapy
  • Rose Bengal/chemistry
  • Ultrasonography


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