Microbubble-sonosensitiser conjugates as therapeutics in sonodynamic therapy

Nikolitsa Nomikou, Colin Fowley, Niall M Byrne, Bridgeen McCaughan, Anthony P McHale, John F Callan

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

A Rose Bengal sonosensitiser has been covalently attached to a lipid microbubble and the resulting conjugate shown to produce higher levels of singlet oxygen, enhanced cytotoxicity in a cancer cell line and a greater reduction in tumour growth than the sonosensitiser alone.

Original languageEnglish
Pages (from-to)8332-4
Number of pages3
JournalChemical Communications
Volume48
Issue number67
DOIs
Publication statusPublished - 28 Aug 2012
Externally publishedYes

Keywords

  • Cell Line, Tumor
  • Drug Delivery Systems
  • Humans
  • Microbubbles/therapeutic use
  • Models, Biological
  • Molecular Structure
  • Neoplasms/therapy
  • Rose Bengal/chemistry
  • Ultrasonography

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  • Cite this

    Nomikou, N., Fowley, C., Byrne, N. M., McCaughan, B., McHale, A. P., & Callan, J. F. (2012). Microbubble-sonosensitiser conjugates as therapeutics in sonodynamic therapy. Chemical Communications, 48(67), 8332-4. https://doi.org/10.1039/c2cc33913g