Microcirculatory hemodynamics and endothelial dysfunction in systemic lupus erythematosus.

Stephen Wright, Aubrey Bell, Gary McVeigh, Dennis Johnston, F.M. O'Prey, D.J. Rea, R. Plumb, A.J. Gamble, W.J. Leahey, [No Value] Devine

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)

Abstract

OBJECTIVE: Impaired flow-mediated dilation (FMD) occurs in disease states associated with atherosclerosis, including SLE. The primary hemodynamic determinant of FMD is wall shear stress, which is critically dependent on the forearm microcirculation. We explored the relationship between FMD, diastolic shear stress (DSS), and the forearm microcirculation in 32 patients with SLE and 19 controls. METHODS AND RESULTS: DSS was calculated using (mean diastolic velocity x 8 x blood viscosity)/baseline brachial artery diameter. Doppler velocity envelopes from the first 15 seconds of reactive hyperemia were analyzed for resistive index (RI), and interrogated in the frequency domain to assess forearm microvascular hemodynamics. FMD was significantly impaired in SLE patients (median, 2.4%; range, -2.1% to 10.7% versus median 5.8%; range, 1.9% to 14%; P
Original languageEnglish
Pages (from-to)2281-2287
Number of pages7
JournalArteriosclerosis Thrombosis and Vascular Biology
Volume26(10)
Issue number10
DOIs
Publication statusPublished - Jul 2006

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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