Microfluidic manufacturing of phospholipid nanoparticles: Stability, encapsulation efficacy, and drug release

Mariana Guimarães Sá Correia, Maria L. Briuglia, Fabio Niosi, Dimitrios A. Lamprou*

*Corresponding author for this work

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Liposomes have been the centre of attention in research due to their potential to act as drug delivery systems. Although its versatility and manufacturing processes are still not scalable and reproducible. In this study, the microfluidic method for liposomes preparation is presented. DMPC and DSPC liposomes containing two different lipid/cholesterol ratios (1:1 and 2:1) are prepared. Results from this preparation process were compared with the film hydration method in order to understand benefits and drawbacks of microfluidics. Liposomes characterisation was evaluated through stability studies, encapsulation efficacy and drug release profiles of hydrophilic and lipophilic compounds. Stability tests were performed during 3 weeks and the liposomes properties of the most stable formulations were determined using Infrared Microscopy and Atomic Force Microscopy. Microfluidic allows loading of drugs and assembly in a quick single step and the chosen flow ratio for liposomes formulation plays a fundamental role for particle sizes. One hydrophilic and one lipophilic compounds were incorporated showing how formulation and physic-chemical characteristics can influence the drug release profile.

Original languageEnglish
Pages (from-to)91-99
Number of pages9
JournalInternational Journal of Pharmaceutics
Volume516
Issue number1-2
Early online date10 Nov 2016
DOIs
Publication statusPublished - 10 Jan 2017
Externally publishedYes

Keywords

  • Controlled release
  • Encapsulation efficacy
  • Liposomes
  • Microfluidics

ASJC Scopus subject areas

  • Pharmaceutical Science

Fingerprint Dive into the research topics of 'Microfluidic manufacturing of phospholipid nanoparticles: Stability, encapsulation efficacy, and drug release'. Together they form a unique fingerprint.

Cite this