Microfluidic methods for liposome formation

Calvin C.L. Cheung; Wafa’ T.  Al-Jamal

doi:10.1016/B978-0-443-15491-1.00024-9

Microfluidic methods for liposome formation

Calvin C.L. Cheung, Wafa’ T. Al-Jamal

School of Pharmacy

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

Abstract

Microfluidic is an emerging technology for the preparation of liposomes. Precise control of fluid flow and mixing offers self-assembly of lipids into homogeneous liposomes with tunable sizes through simple flow rate optimization. Continuous flow and parallelization allow seamless scale-up production for meeting clinical manufacturing demands. Multifunctional microfluidic modules can be designed for in-line drug loading and purification. Microfluidic-assisted methods can also be utilized to prepare lipid-based gene delivery systems, such as RNA-delivery systems. This book chapter summarizes the state-of-the-art microfluidic technology in liposome production for drugs and biologics (proteins and nucleic acids) delivery and its applicability to clinical applications.

Original language	English
Title of host publication	Liposomes in drug delivery. What, where, how and when to deliver
Editors	Sophia G. Antimisiaris
Publisher	Elsevier
Chapter	21
Pages	539-557
ISBN (Print)	9780443154911
DOIs	https://doi.org/10.1016/B978-0-443-15491-1.00024-9
Publication status	Published - 12 Apr 2024

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abstract = "Microfluidic is an emerging technology for the preparation of liposomes. Precise control of fluid flow and mixing offers self-assembly of lipids into homogeneous liposomes with tunable sizes through simple flow rate optimization. Continuous flow and parallelization allow seamless scale-up production for meeting clinical manufacturing demands. Multifunctional microfluidic modules can be designed for in-line drug loading and purification. Microfluidic-assisted methods can also be utilized to prepare lipid-based gene delivery systems, such as RNA-delivery systems. This book chapter summarizes the state-of-the-art microfluidic technology in liposome production for drugs and biologics (proteins and nucleic acids) delivery and its applicability to clinical applications.",

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AU - Al-Jamal, Wafa’ T.

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AB - Microfluidic is an emerging technology for the preparation of liposomes. Precise control of fluid flow and mixing offers self-assembly of lipids into homogeneous liposomes with tunable sizes through simple flow rate optimization. Continuous flow and parallelization allow seamless scale-up production for meeting clinical manufacturing demands. Multifunctional microfluidic modules can be designed for in-line drug loading and purification. Microfluidic-assisted methods can also be utilized to prepare lipid-based gene delivery systems, such as RNA-delivery systems. This book chapter summarizes the state-of-the-art microfluidic technology in liposome production for drugs and biologics (proteins and nucleic acids) delivery and its applicability to clinical applications.

U2 - 10.1016/B978-0-443-15491-1.00024-9

DO - 10.1016/B978-0-443-15491-1.00024-9

M3 - Chapter (peer-reviewed)

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EP - 557

BT - Liposomes in drug delivery. What, where, how and when to deliver

A2 - Antimisiaris, Sophia G.

PB - Elsevier

ER -

Microfluidic methods for liposome formation

Abstract

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