Microneedle applications in improving skin appearance

Maelíosa T. C. McCrudden, Emma McAlister, Aaron Courtenay, Patricia González-Vázquez, Thakur Raghu Raj Singh, Ryan F. Donnelly

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Microneedles (MNs) are micron-sized, minimally invasive devices that breach the outermost layer of the skin, the stratum corneum (SC), creating transient, aqueous pores in the skin and facilitating the transport of therapeutic molecules into the epidermis. Following many years of extensive research in the area of MN-mediated trans- and intra-dermal drug delivery, MNs are now being exploited in the cosmeceutical industry as a means of disrupting skin cell architecture, inducing elastin and collagen expression and deposition. They are also being used as vehicles to deliver cosmeceutic molecules across the skin, in addition to their use in combinatorial treatments with topical agents or light sources. This review explores the chronology of microneedling methodologies, which has led to the emergence of MN devices, now extensively used in cosmeceutical applications. Recent developments in therapeutic molecule and peptide delivery to the skin via MN platforms are addressed and some commercially available MN devices are described. Important safety and regulatory considerations relating to MN usage are addressed, as are studies relating to public perception of MN, as these will undoubtedly influence the acceptance of MN products as they progress towards commercialisation.

Original languageEnglish
Pages (from-to)561-566
Number of pages6
JournalExperimental dermatology
Volume24
Issue number8
Early online date26 May 2015
DOIs
Publication statusPublished - Aug 2015

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