Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 1 - 32 |
| Number of pages | 32 |
| Journal | Materials Science and Engineering: R: Reports |
| Volume | 104 |
| Early online date | 13 Apr 2016 |
| DOIs | |
| Publication status | Published - Jun 2016 |
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Keywords
- Microfabrication
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Microneedle arrays as transdermal and intradermal drug delivery systems: Materials science, manufacture and commercial development. / Larrañeta, Eneko; Lutton, Rebecca E.M.; Woolfson, A. David; Donnelly, Ryan F.
In: Materials Science and Engineering: R: Reports, Vol. 104, 06.2016, p. 1 - 32.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Microneedle arrays as transdermal and intradermal drug delivery systems: Materials science, manufacture and commercial development
AU - Larrañeta, Eneko
AU - Lutton, Rebecca E.M.
AU - Woolfson, A. David
AU - Donnelly, Ryan F.
PY - 2016/6
Y1 - 2016/6
N2 - Transdermal drug delivery offers a number of advantages for the patient, due not only its non-invasive and convenient nature, but also factors such as avoidance of first pass metabolism and prevention of gastrointestinal degradation. It has been demonstrated that microneedle arrays can increase the number of compounds amenable to transdermal delivery by penetrating the skin's protective barrier, the stratum corneum, and creating a pathway for drug permeation to the dermal tissue below. Microneedles have been extensively investigated in recent decades for drug and vaccine delivery as well as minimally invasive patient monitoring/diagnosis. This review focuses on a range of critically important aspects of microneedle technology, namely their material composition, manufacturing techniques, methods of evaluation and commercial translation to the clinic for patient benefit and economic return. Microneedle research and development is finally now at the stage where commercialisation is a realistic possibility. However, progress is still required in the areas of scaled-up manufacture and regulatory approval.
AB - Transdermal drug delivery offers a number of advantages for the patient, due not only its non-invasive and convenient nature, but also factors such as avoidance of first pass metabolism and prevention of gastrointestinal degradation. It has been demonstrated that microneedle arrays can increase the number of compounds amenable to transdermal delivery by penetrating the skin's protective barrier, the stratum corneum, and creating a pathway for drug permeation to the dermal tissue below. Microneedles have been extensively investigated in recent decades for drug and vaccine delivery as well as minimally invasive patient monitoring/diagnosis. This review focuses on a range of critically important aspects of microneedle technology, namely their material composition, manufacturing techniques, methods of evaluation and commercial translation to the clinic for patient benefit and economic return. Microneedle research and development is finally now at the stage where commercialisation is a realistic possibility. However, progress is still required in the areas of scaled-up manufacture and regulatory approval.
KW - Microfabrication
U2 - 10.1016/j.mser.2016.03.001
DO - 10.1016/j.mser.2016.03.001
M3 - Review article
VL - 104
SP - 1
EP - 32
JO - Materials Science and Engineering: R: Reports
JF - Materials Science and Engineering: R: Reports
SN - 0927-796X
ER -