Microneedle-mediated delivery of donepezil: Potential for improved treatment options in Alzheimer's disease

Mary-Carmel Kearney, Ester Caffarel-Salvador, Steven J Fallows, Helen O McCarthy, Ryan F Donnelly

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)
581 Downloads (Pure)

Abstract

Transdermal drug delivery is an attractive route of drug administration, however there are relatively few marketed transdermal products. To increase delivery across the skin, strategies to enhance skin permeability are widely investigated, with microneedles demonstrating particular promise. Hydrogel-forming microneedles are inserted into the skin, and following dissolution of a drug loaded reservoir and movement of the drug through the created channels, the microneedle array is removed intact, and can then be readily and safely discarded. This study presents the formulation and evaluation of an integrated microneedle patch containing the Alzheimer's drug, donepezil hydrochloride. The integrated patch consisted of hydrogel-forming microneedles in combination with a donepezil hydrochloride containing film. Formulation and characterisation of plasticised films, prepared from poly(vinylpyrrolidone) or poly (methyl vinyl ether co-maleic anhydride/acid) (Gantrez(®)) polymers, is presented. Furthermore, in vitro permeation of donepezil hydrochloride across neonatal porcine skin from the patches was investigated, with 854.71 μg ± 122.71 μg donepezil hydrochloride delivered after 24 h, using the optimum patch formulation. Following administration of the patch to an animal model, plasma concentrations of 51.8 ± 17.6 ng/mL were obtained, demonstrating the success of this delivery platform for donepezil hydrochloride.

Original languageEnglish
Pages (from-to)43-50
Number of pages8
JournalEuropean Journal of Pharmaceutics and Biopharmaceutics
Volume103
Early online date24 Mar 2016
DOIs
Publication statusPublished - 01 Jun 2016

Fingerprint Dive into the research topics of 'Microneedle-mediated delivery of donepezil: Potential for improved treatment options in Alzheimer's disease'. Together they form a unique fingerprint.

Cite this