Abstract
Microneedle arrays (MNA) are considered as one of the most promising resources to achieve systemic effects by transdermal delivery of drugs. They are designed as a minimally invasive, painless system which can bypass the stratum corneum, overcoming the potential drawbacks of subcutaneous injections and other transdermal delivery systems such as chemical enhancers, nano and microparticles, or physical treatments. As a trendy field in pharmaceutical and biomedical research, its applications are constantly evolving, even though they are based on very well‐established techniques. The number of molecules administered by MNA are also increasing, with insulin and vaccines administration being the most investigated. Furthermore, MNA are being used to deliver cells and applied in other organs and tissues like the eyes and buccal mucosae. This review intends to offer a general overview of the current state of MNA research, focusing on the strategies, applications, and types of molecules delivered recently by these systems. In addition, some information about the materials and manufacturing processes is presented and safety data is discussed.
| Original language | English |
|---|---|
| Article number | 569 |
| Pages (from-to) | 1-28 |
| Number of pages | 28 |
| Journal | Pharmaceutics |
| Volume | 12 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 19 Jun 2020 |
Keywords
- Microneedle array
- Microneedles
- Skin
- Stratum corneum
- Transdermal delivery
ASJC Scopus subject areas
- Pharmaceutical Science
Access to Document
- Microneedle‐based delivery: An overview of current applications and trends
Copyright 2020 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.