Microneedles as the technique of drug delivery enhancement in diverse organs and tissues

Alexey Rzhevskiy, Raghu Thakur, Ryan Donnelly, Yuri Anissimov

Research output: Contribution to journalArticle

46 Citations (Scopus)
867 Downloads (Pure)

Abstract

Microneedles is the technique of drug delivery enhancement, which was primarily designed for facilitating percutaneous drug delivery. Started from the development of simple solid microneedles, providing microporation of stratum corneum and therefore enhancement of topical drug delivery, for two decades the technique has progressed in various modifications such as hollow, coated, dissolving and hydrogel forming microneedles. In their turn, the modifications have resulted in new mechanisms of drug delivery enhancement and followed by the expansion of applicability range in terms of targeted tissues and organs. Thus, in addition to percutaneous drug delivery, microneedles have been considered as an efficient technique facilitating ocular, oral mucosal, gastrointestinal, ungual and vaginal drug administration. It is anticipated that the technique of microneedle-assisted drug delivery will soon become relevant for majority of organs and tissues.
Original languageEnglish
Pages (from-to)184-202
JournalJournal of Controlled Release
Volume270
Early online date02 Dec 2017
DOIs
Publication statusPublished - 28 Jan 2018

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