MicroRNA as Therapeutic Targets for Chronic Wound Healing

Eoghan Mulholland, Nicholas Dunne, Helen McCarthy

Research output: Contribution to journalReview article

20 Citations (Scopus)
98 Downloads (Pure)

Abstract

Wound healing is a highly complex biological process composed of three overlapping phases: inflammation, proliferation, and remodeling. Impairments at any one or more of these stages can lead to compromised healing. MicroRNAs (miRs) are non-coding RNAs that act as post-transcriptional regulators of multiple proteins and associated pathways. Thus, identification of the appropriate miR involved in the different phases of wound healing could reveal an effective third-generation genetic therapy in chronic wound care. Several miRs have been shown to be upregulated or downregulated during the wound healing process. This article examines the biological processes involved in wound healing, the miR involved at each stage, and how expression levels are modulated in the chronic wound environment. Key miRs are highlighted as possible therapeutic targets, either through underexpression or overexpression, and the healing benefits are interrogated. These are prime miR candidates that could be considered as a gene therapy option for patients suffering from chronic wounds. The success of miR as a gene therapy, however, is reliant on the development of an appropriate delivery system that must be designed to overcome both extracellular and intracellular barriers
Original languageEnglish
Pages (from-to)46-55
JournalMolecular Therapy: Nucleic Acids
Volume8
DOIs
Publication statusPublished - 15 Sep 2017

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MicroRNAs
Wound Healing
Genetic Therapy
Biological Phenomena
Wounds and Injuries
Untranslated RNA
Therapeutics
Down-Regulation
Inflammation
Proteins

Cite this

Mulholland, Eoghan ; Dunne, Nicholas ; McCarthy, Helen. / MicroRNA as Therapeutic Targets for Chronic Wound Healing. In: Molecular Therapy: Nucleic Acids. 2017 ; Vol. 8. pp. 46-55.
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MicroRNA as Therapeutic Targets for Chronic Wound Healing. / Mulholland, Eoghan; Dunne, Nicholas ; McCarthy, Helen.

In: Molecular Therapy: Nucleic Acids, Vol. 8, 15.09.2017, p. 46-55.

Research output: Contribution to journalReview article

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AB - Wound healing is a highly complex biological process composed of three overlapping phases: inflammation, proliferation, and remodeling. Impairments at any one or more of these stages can lead to compromised healing. MicroRNAs (miRs) are non-coding RNAs that act as post-transcriptional regulators of multiple proteins and associated pathways. Thus, identification of the appropriate miR involved in the different phases of wound healing could reveal an effective third-generation genetic therapy in chronic wound care. Several miRs have been shown to be upregulated or downregulated during the wound healing process. This article examines the biological processes involved in wound healing, the miR involved at each stage, and how expression levels are modulated in the chronic wound environment. Key miRs are highlighted as possible therapeutic targets, either through underexpression or overexpression, and the healing benefits are interrogated. These are prime miR candidates that could be considered as a gene therapy option for patients suffering from chronic wounds. The success of miR as a gene therapy, however, is reliant on the development of an appropriate delivery system that must be designed to overcome both extracellular and intracellular barriers

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