MicroRNA regulation of core apoptosis pathways in cancer

R.T. Lima; Sara Busacca; G.M. Almeida; G. Gaudino; Dean Fennell; M.H. Vasconcelos

doi:10.1016/j.ejca.2010.11.005

MicroRNA regulation of core apoptosis pathways in cancer

R.T. Lima, Sara Busacca, G.M. Almeida, G. Gaudino, Dean Fennell, M.H. Vasconcelos

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

247 Citations (Scopus)

Abstract

Recent research has demonstrated that microRNAs (miRNAs) are key regulators of many cell processes often deregulated in cancer, including apoptosis. Indeed, it is becoming clear that many miRNAs are anti-apoptotic and mediate this effect by targeting pro-apoptotic mRNAs or positive regulators of pro-apoptotic mRNAs. Conversely, many pro-apoptotic miRNAs target anti-apoptotic mRNAs or their positive regulators. We have reviewed the current knowledge in this area including evidence of miRNA involvement in cancer drug resistance. (C) 2010 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	163-174
Number of pages	12
Journal	European Journal of Cancer
Volume	47
Issue number	2
DOIs	https://doi.org/10.1016/j.ejca.2010.11.005
Publication status	Published - Jan 2011

ASJC Scopus subject areas

Cancer Research
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ejca.2010.11.005

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title = "MicroRNA regulation of core apoptosis pathways in cancer",

abstract = "Recent research has demonstrated that microRNAs (miRNAs) are key regulators of many cell processes often deregulated in cancer, including apoptosis. Indeed, it is becoming clear that many miRNAs are anti-apoptotic and mediate this effect by targeting pro-apoptotic mRNAs or positive regulators of pro-apoptotic mRNAs. Conversely, many pro-apoptotic miRNAs target anti-apoptotic mRNAs or their positive regulators. We have reviewed the current knowledge in this area including evidence of miRNA involvement in cancer drug resistance. (C) 2010 Elsevier Ltd. All rights reserved.",

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AU - Busacca, Sara

AU - Almeida, G.M.

AU - Gaudino, G.

AU - Fennell, Dean

AU - Vasconcelos, M.H.

PY - 2011/1

Y1 - 2011/1

N2 - Recent research has demonstrated that microRNAs (miRNAs) are key regulators of many cell processes often deregulated in cancer, including apoptosis. Indeed, it is becoming clear that many miRNAs are anti-apoptotic and mediate this effect by targeting pro-apoptotic mRNAs or positive regulators of pro-apoptotic mRNAs. Conversely, many pro-apoptotic miRNAs target anti-apoptotic mRNAs or their positive regulators. We have reviewed the current knowledge in this area including evidence of miRNA involvement in cancer drug resistance. (C) 2010 Elsevier Ltd. All rights reserved.

AB - Recent research has demonstrated that microRNAs (miRNAs) are key regulators of many cell processes often deregulated in cancer, including apoptosis. Indeed, it is becoming clear that many miRNAs are anti-apoptotic and mediate this effect by targeting pro-apoptotic mRNAs or positive regulators of pro-apoptotic mRNAs. Conversely, many pro-apoptotic miRNAs target anti-apoptotic mRNAs or their positive regulators. We have reviewed the current knowledge in this area including evidence of miRNA involvement in cancer drug resistance. (C) 2010 Elsevier Ltd. All rights reserved.

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DO - 10.1016/j.ejca.2010.11.005

M3 - Article

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SP - 163

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JO - European Journal of Cancer

JF - European Journal of Cancer

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MicroRNA regulation of core apoptosis pathways in cancer

Abstract

ASJC Scopus subject areas

UN SDGs

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