MicroRNA regulation of core apoptosis pathways in cancer

R.T. Lima, Sara Busacca, G.M. Almeida, G. Gaudino, Dean Fennell, M.H. Vasconcelos

Research output: Contribution to journalArticle

198 Citations (Scopus)

Abstract

Recent research has demonstrated that microRNAs (miRNAs) are key regulators of many cell processes often deregulated in cancer, including apoptosis. Indeed, it is becoming clear that many miRNAs are anti-apoptotic and mediate this effect by targeting pro-apoptotic mRNAs or positive regulators of pro-apoptotic mRNAs. Conversely, many pro-apoptotic miRNAs target anti-apoptotic mRNAs or their positive regulators. We have reviewed the current knowledge in this area including evidence of miRNA involvement in cancer drug resistance. (C) 2010 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)163-174
Number of pages12
JournalEuropean Journal of Cancer
Volume47
Issue number2
DOIs
Publication statusPublished - Jan 2011

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Lima, R. T., Busacca, S., Almeida, G. M., Gaudino, G., Fennell, D., & Vasconcelos, M. H. (2011). MicroRNA regulation of core apoptosis pathways in cancer. European Journal of Cancer, 47(2), 163-174. https://doi.org/10.1016/j.ejca.2010.11.005