Migrating Schistosoma japonicum schistosomula induce an innate immune response and wound healing in the murine lung

Melissa L. Burke*, Laken McGarvey, Henry J. McSorley, Helle Bielefeldt-Ohmann, Donald P. McManus, Geoffrey N. Gobert

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

The migrating schistosomulum is an important stage of the schistosome lifecycle and represents a key target for elimination of infection by natural and vaccine-induced host immune responses. To gain a better understanding of how schistosomes initiate a primary host immune response we have characterised the host lung response to migrating Schistosoma japonicum schistosomula using a combination of histopathology, microarray analysis and real-time PCR. Our findings indicate that the early pulmonary response to these migrating larvae is characteristic of innate inflammation and wound healing. This response is associated with significant up-regulation of several genes with immunoregulatory function including Ch25h, Hmox1 and Retnla which may act to control the nature or magnitude of the inflammatory response to the migrating schistosomula, promoting both parasite and host survival. These findings contribute to our understanding of host-parasite interactions associated with schistosome and, especially, S. japonicum infection, and may aid the future design of novel vaccines that target the lung stage schistosomulum.

Original languageEnglish
Pages (from-to)191-200
Number of pages10
JournalMolecular Immunology
Volume49
Issue number1-2
DOIs
Publication statusPublished - 01 Oct 2011
Externally publishedYes

Keywords

  • Lung
  • Microarray
  • Primary immune response
  • Schistosoma japonicum
  • Schistosomula

ASJC Scopus subject areas

  • Molecular Biology
  • Immunology

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