Abstract
A mild calcium catalysed Beckmann rearrangement has been realised, which forgoes the more traditional harsh reactions conditions associated with the transformation. The catalyst system is shown to be tolerant towards a wide variety of functional groups relevant to natural product synthesis and medicinal chemistry and the synthetic utility of the reaction has also been investigated. A preliminary mechanistic investigation was performed to understand the nature of the incoming nucleophile and a possible reaction pathway is described.
Original language | English |
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Pages (from-to) | 654-657 |
Number of pages | 4 |
Journal | Chemical Communications |
Volume | 54 |
Early online date | 21 Dec 2017 |
DOIs | |
Publication status | Published - 18 Jan 2018 |
Externally published | Yes |