Mild, calcium catalysed Beckmann rearrangements

H. J. Kiely-Collins, I. Sechi, P. E. Brennan*, M. G. McLaughlin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)
19 Downloads (Pure)

Abstract

A mild calcium catalysed Beckmann rearrangement has been realised, which forgoes the more traditional harsh reactions conditions associated with the transformation. The catalyst system is shown to be tolerant towards a wide variety of functional groups relevant to natural product synthesis and medicinal chemistry and the synthetic utility of the reaction has also been investigated. A preliminary mechanistic investigation was performed to understand the nature of the incoming nucleophile and a possible reaction pathway is described.

Original languageEnglish
Pages (from-to)654-657
Number of pages4
JournalChemical Communications
Volume54
Early online date21 Dec 2017
DOIs
Publication statusPublished - 18 Jan 2018
Externally publishedYes

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