Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro.

EC Patin; S Willcocks; S Orr; TH Ward; R Lang; UE Schaible

doi:10.1177/1753425916636671

Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro.

EC Patin, S Willcocks, S Orr, TH Ward, R Lang, UE Schaible

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

136 Downloads (Pure)

Abstract

The role of macrophage-inducible C-type lectin (Mincle) in anti-inflammatory responses has not yet been fully characterized. Herein, we show that engagement of Mincle by trehalose-dimycolate or mycobacteria promotes IL-10 production in macrophages, which causes down-regulation of IL-12p40 secretion. Thus, Mincle mediates both pro- as well as anti-inflammatory responses.

Original language	English
Journal	Innate Immunity
Early online date	01 Mar 2016
DOIs	https://doi.org/10.1177/1753425916636671
Publication status	Published - 01 Apr 2016

Access to Document

10.1177/1753425916636671Licence: CC BY

Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro
Copyright 2016 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 395 KBLicence: CC BY

Cite this

@article{aeaa3a4da0494f5fb957e624d3da4b22,

title = "Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro.",

abstract = "The role of macrophage-inducible C-type lectin (Mincle) in anti-inflammatory responses has not yet been fully characterized. Herein, we show that engagement of Mincle by trehalose-dimycolate or mycobacteria promotes IL-10 production in macrophages, which causes down-regulation of IL-12p40 secretion. Thus, Mincle mediates both pro- as well as anti-inflammatory responses.",

author = "EC Patin and S Willcocks and S Orr and TH Ward and R Lang and UE Schaible",

year = "2016",

month = apr,

day = "1",

doi = "10.1177/1753425916636671",

language = "English",

journal = "Innate Immunity",

issn = "1753-4259",

publisher = "SAGE Publications Ltd",

}

TY - JOUR

T1 - Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro.

AU - Patin, EC

AU - Willcocks, S

AU - Orr, S

AU - Ward, TH

AU - Lang, R

AU - Schaible, UE

PY - 2016/4/1

Y1 - 2016/4/1

N2 - The role of macrophage-inducible C-type lectin (Mincle) in anti-inflammatory responses has not yet been fully characterized. Herein, we show that engagement of Mincle by trehalose-dimycolate or mycobacteria promotes IL-10 production in macrophages, which causes down-regulation of IL-12p40 secretion. Thus, Mincle mediates both pro- as well as anti-inflammatory responses.

AB - The role of macrophage-inducible C-type lectin (Mincle) in anti-inflammatory responses has not yet been fully characterized. Herein, we show that engagement of Mincle by trehalose-dimycolate or mycobacteria promotes IL-10 production in macrophages, which causes down-regulation of IL-12p40 secretion. Thus, Mincle mediates both pro- as well as anti-inflammatory responses.

UR - http://europepmc.org/abstract/med/26939595

U2 - 10.1177/1753425916636671

DO - 10.1177/1753425916636671

M3 - Article

C2 - 26939595

SN - 1753-4259

JO - Innate Immunity

JF - Innate Immunity

ER -

Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro.

Abstract

Access to Document

Other files and links

Fingerprint

Cite this