Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro.

EC Patin, S Willcocks, S Orr, TH Ward, R Lang, UE Schaible

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)
67 Downloads (Pure)

Abstract

The role of macrophage-inducible C-type lectin (Mincle) in anti-inflammatory responses has not yet been fully characterized. Herein, we show that engagement of Mincle by trehalose-dimycolate or mycobacteria promotes IL-10 production in macrophages, which causes down-regulation of IL-12p40 secretion. Thus, Mincle mediates both pro- as well as anti-inflammatory responses.
Original languageEnglish
JournalInnate Immunity
Early online date01 Mar 2016
DOIs
Publication statusPublished - 01 Apr 2016

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