Minimally-invasive patient monitoring and diagnosis using microneedles.

Aaron J. Courtenay, Marco T.A. Abbate, Maelíosa T.C. McCrudden, Ryan F. Donnelly*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter outlines some of the important patent filings and devices developed in microneedle (MN) technology, pertaining to fluid extraction and drug analysis. It highlights some of the methods reported in the literature used to access interstitial fluid (ISF) and whole blood using minimally- and non-invasive sampling techniques. Specific analyte monitoring has grown in popularity with many publications focusing on minimally and non-invasive glucose monitoring. Therapeutic drug monitoring can be used to diagnose acute and chronic conditions. Therapeutic monitoring in patients refers to a system of analyses aimed at the detection and quantification of drugs or endogenous markers primarily from serum or plasma matrices. Disease diagnosis, particularly of infectious diseases where testing is validated and available, is a real concern in the developing world. The chapter also outlines some of the most basic principles governing the success or failure of an MN patch/device for ISF or whole blood sampling.
Original languageEnglish
Title of host publicationMicroneedles for drug and vaccine delivery and patient monitoring
EditorsRyan F Donnelly
PublisherJohn Wiley & Sons Ltd
Chapter7
Pages207-234
ISBN (Electronic)9781119305101
ISBN (Print)9781119305149
DOIs
Publication statusPublished - 2018

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