Mitigative potential of statin therapy in base-mediated radiation cardiotoxicity

We highlighted that the predisposition to GI toxicity requires an understanding of the gut MB both at the ecological and at the functional level. Our analysis suggests that an altered ion homeostasis at the level of bacterial communities might predispose pts to the onset of GI toxicity. The predictive features identified are the relative abundance of genera Faecalibacterium, Bacteroides, Parabacteroides, Alistipes, Prevotella and Phascolarctobaterium and seem to generalize prediction beyond sequencing technology and platforms and overcome potential bias associated with the ethnic origin of patients(at least for what concern western European countries). The study opens up concrete prospects for the use of baseline faecal samples in the clinical practice to improve pre-RT toxicity risk assessment and RT planning optimization.