Mitochondria as a target for radiosensitisation by gold nanoparticles

S. J. McMahon; A. L. McNamara; J. Schuemann; K. M. Prise; H. Paganetti

doi:10.1088/1742-6596/777/1/012008

Mitochondria as a target for radiosensitisation by gold nanoparticles

S. J. McMahon, A. L. McNamara, J. Schuemann, K. M. Prise, H. Paganetti

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Abstract

While Gold Nanoparticles (GNPs) have been extensively studied as radiosensitisers in recent years, there is a lack of studies of their impact on targets outside of the cell's nuclear DNA. We present Monte Carlo simulations of the energy deposited by X-ray irradiation in mitochondria in cells with and without cytoplasmic GNPs. These simulations show that the presence of GNPs within the cytoplasm can significantly increase (3-4 fold) the number of ionisation clusters of both small and large sizes. As these clusters are strongly associated with DNA damage, these results suggest that mitochondrial DNA may be a significant target for GNP radiosensitisation when the nanoparticles cannot penetrate the cell nucleus.

Original language	English
Article number	012008
Journal	Journal of Physics: Conference Series
Volume	777
Issue number	1
DOIs	https://doi.org/10.1088/1742-6596/777/1/012008
Publication status	Published - 03 Feb 2017

ASJC Scopus subject areas

General Physics and Astronomy

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10.1088/1742-6596/777/1/012008Licence: CC BY

Mitochondria as a target for radiosensitisation by gold nanoparticles
Copyright 2017 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
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abstract = "While Gold Nanoparticles (GNPs) have been extensively studied as radiosensitisers in recent years, there is a lack of studies of their impact on targets outside of the cell's nuclear DNA. We present Monte Carlo simulations of the energy deposited by X-ray irradiation in mitochondria in cells with and without cytoplasmic GNPs. These simulations show that the presence of GNPs within the cytoplasm can significantly increase (3-4 fold) the number of ionisation clusters of both small and large sizes. As these clusters are strongly associated with DNA damage, these results suggest that mitochondrial DNA may be a significant target for GNP radiosensitisation when the nanoparticles cannot penetrate the cell nucleus.",

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AU - Paganetti, H.

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AB - While Gold Nanoparticles (GNPs) have been extensively studied as radiosensitisers in recent years, there is a lack of studies of their impact on targets outside of the cell's nuclear DNA. We present Monte Carlo simulations of the energy deposited by X-ray irradiation in mitochondria in cells with and without cytoplasmic GNPs. These simulations show that the presence of GNPs within the cytoplasm can significantly increase (3-4 fold) the number of ionisation clusters of both small and large sizes. As these clusters are strongly associated with DNA damage, these results suggest that mitochondrial DNA may be a significant target for GNP radiosensitisation when the nanoparticles cannot penetrate the cell nucleus.

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Mitochondria as a target for radiosensitisation by gold nanoparticles

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