Mitochondrial J haplogroup is associated with lower blood pressure and anti-oxidant status: findings in octo/nonagenarians from the BELFAST Study

Irene Maeve Rea, Susan E. McNerlan, G. Pooler Archbold, Derek Middleton, Martin D. Curran, Ian S. Young, Owen A. Ross

Research output: Contribution to journalArticle

10 Citations (Scopus)
252 Downloads (Pure)

Abstract

Mitochondria produce cellular energy but also free-radicals, which damage cells despite an array of endogenous anti-oxidants. In Northern Europe, the mitochondrial haplogroup J has been related to longevity in nonagenarians and centenarians but also with age-related disease. Hypertension is an important contributor to atherosclerotic-related diseases and its pathogenesis is associated with increased oxidative stress. In this study, we questioned whether J haplogroup octo/nonagenarians from the Belfast Elderly Longitudinal Free-living Elderly STudy (BELFAST) study showed evidence of protective blood pressure or anti-oxidant profile which might explain their longevity advantage. Briefly, in a cross-sectional study, community-living, mentally alert (Folstein >25/30), octo/nonagenarian subjects, recruited for good health, were enlisted and consented as part of the BELFAST study, for blood pressure, anthropometric measurements and blood sampling. DNA typing for mitochondrial haplotypes was carried out with measurements for enzymatic and non-enzymatic antioxidants. J haplogroup carriers showed lower systolic blood pressure and glutathione peroxidase activity (Gpx) with higher folate measurements. There was no change in urate, bilirubin, albumin or nutrition-related antioxidants-selenium or vitamins A, C and a and ß carotene. BELFAST study mtDNA J haplogroup octo/nonagenarians showed lower blood pressure and reduced glutathione peroxidase activity and higher folate, but no change for other antioxidants. These findings are of interest in view of mtDNA J haplogroup's association with increased age in some previous studies.
Original languageEnglish
Pages (from-to)1445-1456
Number of pages12
JournalAge (Dordrecht, Netherlands)
Volume35
Issue number4
Early online date10 Jul 2012
DOIs
Publication statusPublished - Aug 2013

Keywords

  • Blood pressure
  • J mitochondrial haplogroup
  • Longevity
  • Antioxidant status
  • Glutathione peroxidase activity
  • Vitamins A, E, C,α and β carotene
  • Urate

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology
  • Medicine(all)

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  • Projects

    R6229GRM: GEHA.

    Rea, M.

    01/08/200417/12/2019

    Project: Research

    Activities

    • 4 Participation in conference
    • 1 Invited talk

    British Society Research into Ageing

    Maeve Rea (Invited speaker)

    07 Jul 201409 Jul 2014

    Activity: Participating in or organising an event typesParticipation in conference

    EuroScion Obesity Summit 2014

    Maeve Rea (Invited speaker)

    01 Apr 2014

    Activity: Participating in or organising an event typesParticipation in conference

    International Symposium: The Challenges of the Biological Research in Aging in the 21st Century: from the cells to the clinics.

    Maeve Rea (Invited speaker)

    02 Nov 201404 Nov 2014

    Activity: Participating in or organising an event typesParticipation in conference

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