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Abstract
Mitochondria produce cellular energy but also free-radicals, which damage cells despite an array of endogenous anti-oxidants. In Northern Europe, the mitochondrial haplogroup J has been related to longevity in nonagenarians and centenarians but also with age-related disease. Hypertension is an important contributor to atherosclerotic-related diseases and its pathogenesis is associated with increased oxidative stress. In this study, we questioned whether J haplogroup octo/nonagenarians from the Belfast Elderly Longitudinal Free-living Elderly STudy (BELFAST) study showed evidence of protective blood pressure or anti-oxidant profile which might explain their longevity advantage. Briefly, in a cross-sectional study, community-living, mentally alert (Folstein >25/30), octo/nonagenarian subjects, recruited for good health, were enlisted and consented as part of the BELFAST study, for blood pressure, anthropometric measurements and blood sampling. DNA typing for mitochondrial haplotypes was carried out with measurements for enzymatic and non-enzymatic antioxidants. J haplogroup carriers showed lower systolic blood pressure and glutathione peroxidase activity (Gpx) with higher folate measurements. There was no change in urate, bilirubin, albumin or nutrition-related antioxidants-selenium or vitamins A, C and a and ß carotene. BELFAST study mtDNA J haplogroup octo/nonagenarians showed lower blood pressure and reduced glutathione peroxidase activity and higher folate, but no change for other antioxidants. These findings are of interest in view of mtDNA J haplogroup's association with increased age in some previous studies.
Original language | English |
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Pages (from-to) | 1445-1456 |
Number of pages | 12 |
Journal | Age (Dordrecht, Netherlands) |
Volume | 35 |
Issue number | 4 |
Early online date | 10 Jul 2012 |
DOIs | |
Publication status | Published - Aug 2013 |
Keywords
- Blood pressure
- J mitochondrial haplogroup
- Longevity
- Antioxidant status
- Glutathione peroxidase activity
- Vitamins A, E, C,α and β carotene
- Urate
ASJC Scopus subject areas
- Ageing
- Geriatrics and Gerontology
- General Medicine
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Dive into the research topics of 'Mitochondrial J haplogroup is associated with lower blood pressure and anti-oxidant status: findings in octo/nonagenarians from the BELFAST Study'. Together they form a unique fingerprint.Projects
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International Symposium: The Challenges of the Biological Research in Aging in the 21st Century: from the cells to the clinics.
Maeve Rea (Invited speaker)
02 Nov 2014 → 04 Nov 2014Activity: Participating in or organising an event types › Participation in conference
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Second International Medical Congress Woman and Man: Healthy Ageing
Maeve Rea (Keynote/plenary speaker)
10 Oct 2014 → 11 Oct 2014Activity: Participating in or organising an event types › Participation in conference
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British Society Research into Ageing
Maeve Rea (Invited speaker)
07 Jul 2014 → 09 Jul 2014Activity: Participating in or organising an event types › Participation in conference
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Open AccessFile194 Citations (Scopus)313 Downloads (Pure) -
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35 Citations (Scopus) -
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Raule, N., Sevini, F., Li, S., Barbieri, A., Tallaro, F., Lomartire, L., Vianello, D., Montesanto, A., Moilanen, J. S., Bezrukov, V., Blanché, H., Hervonen, A., Christensen, K., Deiana, L., Gonos, E. S., Kirkwood, T. B. L., Kristensen, P., Leon, A., Pelicci, P. G. & Poulain, M. & 18 others, , Jun 2014, In: Aging cell. 13, 3, p. 401-407 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile85 Citations (Scopus)391 Downloads (Pure)