Mixed chimaerism; detection and significance following BMT

S R McCann, M Lawler, Mark Lawler

Research output: Contribution to journalArticlepeer-review

61 Citations (Scopus)


Residual recipient haematopoietic cells may coexist with donor haemopoietic tissue following BMT. This is known as mixed chimaerism. The incidence of mixed chimaerism varies with the sensitivity of the detection system used; DNA based methodologies are the most sensitive. The influence of mixed chimaerism on leukaemia relapse and graft rejection is unclear. The lineages in which mixed chimaerism occurs may affect outcome.

Original languageEnglish
Pages (from-to)91-4
Number of pages4
JournalBone Marrow Transplantation
Issue number2
Publication statusPublished - Feb 1993


  • Anemia, Aplastic
  • Bone Marrow Purging
  • Bone Marrow Transplantation
  • Chimera
  • Graft Survival
  • Hematopoietic Stem Cells
  • Humans
  • Leukemia
  • Neoplastic Stem Cells


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