Mixed chimaerism; detection and significance following BMT

S R McCann, M Lawler, Mark Lawler

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Residual recipient haematopoietic cells may coexist with donor haemopoietic tissue following BMT. This is known as mixed chimaerism. The incidence of mixed chimaerism varies with the sensitivity of the detection system used; DNA based methodologies are the most sensitive. The influence of mixed chimaerism on leukaemia relapse and graft rejection is unclear. The lineages in which mixed chimaerism occurs may affect outcome.

Original languageEnglish
Pages (from-to)91-4
Number of pages4
JournalBone Marrow Transplantation
Volume11
Issue number2
Publication statusPublished - Feb 1993

Keywords

  • Anemia, Aplastic
  • Bone Marrow Purging
  • Bone Marrow Transplantation
  • Chimera
  • Graft Survival
  • Hematopoietic Stem Cells
  • Humans
  • Leukemia
  • Neoplastic Stem Cells

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