MMP expression and abnormal lung permeability are important determinants of outcome in IPF

S. McKeown, A.G. Richter, Cecilia O'Kane, Danny McAuley, D.R. Thickett

Research output: Contribution to journalArticlepeer-review

99 Citations (Scopus)

Abstract

Matrix metalloproteinases (MMPs) degrade all of the extracellular matrix components of the intersititium and may play a role in abnormal alveolar permeability, which is a feature of idiopathic pulmonary fibrosis (IPF). The aims of the present study were to evaluate MMP protein levels in patients with IPF and determine any relationship to treatment and markers of permeability.
Original languageEnglish
Pages (from-to)77-84
Number of pages8
JournalEuropean Respiratory Journal
Volume33
Issue number1
DOIs
Publication statusPublished - Jan 2009

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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