MMP expression and abnormal lung permeability are important determinants of outcome in IPF

S. McKeown; A.G. Richter; Cecilia O'Kane; Danny McAuley; D.R. Thickett

doi:10.1183/09031936.00060708

MMP expression and abnormal lung permeability are important determinants of outcome in IPF

S. McKeown, A.G. Richter, Cecilia O'Kane, Danny McAuley, D.R. Thickett

Research output: Contribution to journal › Article › peer-review

167 Citations (Scopus)

Abstract

Matrix metalloproteinases (MMPs) degrade all of the extracellular matrix components of the intersititium and may play a role in abnormal alveolar permeability, which is a feature of idiopathic pulmonary fibrosis (IPF). The aims of the present study were to evaluate MMP protein levels in patients with IPF and determine any relationship to treatment and markers of permeability.

Original language	English
Pages (from-to)	77-84
Number of pages	8
Journal	European Respiratory Journal
Volume	33
Issue number	1
DOIs	https://doi.org/10.1183/09031936.00060708
Publication status	Published - Jan 2009

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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10.1183/09031936.00060708

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title = "MMP expression and abnormal lung permeability are important determinants of outcome in IPF",

abstract = "Matrix metalloproteinases (MMPs) degrade all of the extracellular matrix components of the intersititium and may play a role in abnormal alveolar permeability, which is a feature of idiopathic pulmonary fibrosis (IPF). The aims of the present study were to evaluate MMP protein levels in patients with IPF and determine any relationship to treatment and markers of permeability.",

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AU - McKeown, S.

AU - Richter, A.G.

AU - O'Kane, Cecilia

AU - McAuley, Danny

AU - Thickett, D.R.

PY - 2009/1

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N2 - Matrix metalloproteinases (MMPs) degrade all of the extracellular matrix components of the intersititium and may play a role in abnormal alveolar permeability, which is a feature of idiopathic pulmonary fibrosis (IPF). The aims of the present study were to evaluate MMP protein levels in patients with IPF and determine any relationship to treatment and markers of permeability.

AB - Matrix metalloproteinases (MMPs) degrade all of the extracellular matrix components of the intersititium and may play a role in abnormal alveolar permeability, which is a feature of idiopathic pulmonary fibrosis (IPF). The aims of the present study were to evaluate MMP protein levels in patients with IPF and determine any relationship to treatment and markers of permeability.

UR - https://www.scopus.com/pages/publications/58849094483

U2 - 10.1183/09031936.00060708

DO - 10.1183/09031936.00060708

M3 - Article

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VL - 33

SP - 77

EP - 84

JO - European Respiratory Journal

JF - European Respiratory Journal

IS - 1

ER -

MMP expression and abnormal lung permeability are important determinants of outcome in IPF

Abstract

ASJC Scopus subject areas

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