Modelling the impact of mandatory folic acid fortification of bread or flour in Ireland on the risk of occurrence of NTD-affected pregnancies in women of childbearing age and on risk of masking vitamin B12 deficiency in older adults

Laura Kehoe, Janette Walton, Sinead Hopkins, Breige McNulty, Anne P. Nugent, Albert Flynn

Research output: Contribution to journalArticle

32 Downloads (Pure)

Abstract

Purpose: The rate of neural tube defects (NTDs) in Europe has remained similar since the 1990’s despite folic acid supplement recommendations (400µg/d) for women of childbearing age (WBCA). Mandatory folic acid fortification of staple foods has proved effective for reducing the prevalence of NTDs in over 80 countries. This study estimated the impact of addition of folic acid to bread or flour in the Republic of Ireland on reducing the risk of occurrence of NTD-affected pregnancies and the possible risk of masking (undiagnosed) vitamin B12 deficiency in older adults.
Methods: Analyses were based on the Irish National Adult Nutrition Survey (NANS) (2008-2010). Folic acid fortification was modelled using DaDiet© software. Estimates were made of the increase in average daily folic acid intake in women (18-50 years) and the risk of exceeding the Tolerable Upper Intake Level (UL) of 1,000µg for folic acid in adults over 50 years of age.
Results: The fortification scenarios examined would reduce the risk of NTD-affected pregnancies by 8–32%, corresponding to an increase of 39–152μg in the mean daily folic acid intake of WCBA. The risk of masking anaemia associated with vitamin B12 deficiency in older adults would be negligible as the probability of exceeding the UL for folic acid, even by a small amount, is very low (≤0·2%).
Conclusions: These levels of addition of folic acid to bread or flour would effectively reduce the risk of NTDs while allowing safe consumption of folic acid at current levels from other fortified foods and supplements.
Original languageEnglish
Pages (from-to)2631-2639
JournalEuropean Journal of Nutrition
Early online date23 Oct 2019
DOIs
Publication statusEarly online date - 23 Oct 2019

Fingerprint Dive into the research topics of 'Modelling the impact of mandatory folic acid fortification of bread or flour in Ireland on the risk of occurrence of NTD-affected pregnancies in women of childbearing age and on risk of masking vitamin B12 deficiency in older adults'. Together they form a unique fingerprint.

Cite this