Modification of biomaterial surface characteristics by body fluids in vitro

J.G. McGovern, C.P. Garvin, David Jones, David Woolfson, Sean Gorman

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


In practice, polyvinyl chloride endotracheal tubes and polyurethane urinary catheters are located in areas where they are exposed to the conditioning fluids saliva and urine, respectively. Samples of both biomaterials were incubated in these conditioning fluids and, following treatment, dynamic contact angle measurement and surface roughness assessment by atomic force microscopy were used to analyse surface characteristics. Over a 24 h period of contact with the conditioning fluids, the surface of both materials became significantly more hydrophilic (p
Original languageEnglish
Pages (from-to)251-254
Number of pages4
JournalInternational Journal of Pharmaceutics
Publication statusPublished - 1997


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