Abstract
This review discusses the potential application of bacterial viruses (phage therapy)
towards the eradication of antibiotic resistant Pseudomonas aeruginosa in children with
cystic fibrosis (CF). In this regard, several potential relationships between bacteria and their
bacteriophages are considered. The most important aspect that must be addressed with
respect to phage therapy of bacterial infections in the lungs of CF patients is in ensuring the
continuity of treatment in light of the continual occurrence of resistant bacteria. This
depends on the ability to rapidly select phages exhibiting an enhanced spectrum of lytic
activity among several well-studied phage groups of proven safety. We propose a modular
based approach, utilizing both mono-species and hetero-species phage mixtures. With an
approach involving the visual recognition of characteristics exhibited by phages of well studied
phage groups on lawns of the standard P. aeruginosa PAO1 strain, the simple and
rapid enhancement of the lytic spectrum of cocktails is permitted, allowing the development
of tailored preparations for patients capable of circumventing problems associated with
phage resistant bacterial mutants.
Original language | English |
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Article number | 205902 |
Journal | Frontiers in Biosciences |
DOIs | |
Publication status | Published - 13 Oct 2016 |