Modulated temperature differential scanning calorimetry and its application to freeze-drying

Research output: Contribution to journalArticlepeer-review

Abstract

MTDSC is a software modification of the traditional DSC thermal analysis technique that allows more accurate determination of the glass transition as well as measurement of the endothermic relaxation that often accompanies the transition. The glass transition is an essential parameterboth of the original frozen solution and of the end product. Measurement of endothermic relaxation allows the determination of molecularrelaxation times in the freeze-dried product that may be useful in predicting the effect of formulation variables and storage conditions on physical stability.
Original languageEnglish
Pages (from-to)95-99
Number of pages5
JournalEuropean Journal of Parenteral & Pharmaceutical Sciences
Volume6
Publication statusPublished - Mar 2001

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