Modulation of the conformational state of mitochondrial complex I as a target for therapeutic intervention

Alexander Galkin, Salvador Moncada

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

In recent years, there have been significant advances in our understanding of the functions of mitochondrial complex I other than the generation of energy. These include its role in generation of reactive oxygen species, involvement in the hypoxic tissue response and its possible regulation by nitric oxide (NO) metabolites. In this review, we will focus on the hypoxic conformational change of this mitochondrial enzyme, the so-called active/deactive transition. This conformational change is physiological and relevant to the understanding of certain pathological conditions including, in the cardiovascular system, ischaemia/reperfusion (I/R) damage. We will discuss how complex I can be affected by NO metabolites and will outline some potential mitochondria-targeted therapies in I/R damage.

LanguageEnglish
Pages20160104
JournalInterface Focus
Volume7
Issue number2
DOIs
Publication statusPublished - 17 Feb 2017

Fingerprint

Nitric oxide
Metabolites
Reperfusion Injury
Nitric Oxide
Ischemia
Modulation
Cardiovascular system
Mitochondria
Cardiovascular System
Reactive Oxygen Species
Enzymes
Tissue
Oxygen
Therapeutics

Keywords

  • Journal Article
  • Review

Cite this

Galkin, Alexander ; Moncada, Salvador. / Modulation of the conformational state of mitochondrial complex I as a target for therapeutic intervention. In: Interface Focus. 2017 ; Vol. 7, No. 2. pp. 20160104.
@article{6aa857f51fde4599916b246ccd40c0dd,
title = "Modulation of the conformational state of mitochondrial complex I as a target for therapeutic intervention",
abstract = "In recent years, there have been significant advances in our understanding of the functions of mitochondrial complex I other than the generation of energy. These include its role in generation of reactive oxygen species, involvement in the hypoxic tissue response and its possible regulation by nitric oxide (NO) metabolites. In this review, we will focus on the hypoxic conformational change of this mitochondrial enzyme, the so-called active/deactive transition. This conformational change is physiological and relevant to the understanding of certain pathological conditions including, in the cardiovascular system, ischaemia/reperfusion (I/R) damage. We will discuss how complex I can be affected by NO metabolites and will outline some potential mitochondria-targeted therapies in I/R damage.",
keywords = "Journal Article, Review",
author = "Alexander Galkin and Salvador Moncada",
year = "2017",
month = "2",
day = "17",
doi = "10.1098/rsfs.2016.0104",
language = "English",
volume = "7",
pages = "20160104",
journal = "Interface Focus",
issn = "2042-8898",
publisher = "Royal Society Publishing",
number = "2",

}

Modulation of the conformational state of mitochondrial complex I as a target for therapeutic intervention. / Galkin, Alexander; Moncada, Salvador.

In: Interface Focus, Vol. 7, No. 2, 17.02.2017, p. 20160104.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Modulation of the conformational state of mitochondrial complex I as a target for therapeutic intervention

AU - Galkin, Alexander

AU - Moncada, Salvador

PY - 2017/2/17

Y1 - 2017/2/17

N2 - In recent years, there have been significant advances in our understanding of the functions of mitochondrial complex I other than the generation of energy. These include its role in generation of reactive oxygen species, involvement in the hypoxic tissue response and its possible regulation by nitric oxide (NO) metabolites. In this review, we will focus on the hypoxic conformational change of this mitochondrial enzyme, the so-called active/deactive transition. This conformational change is physiological and relevant to the understanding of certain pathological conditions including, in the cardiovascular system, ischaemia/reperfusion (I/R) damage. We will discuss how complex I can be affected by NO metabolites and will outline some potential mitochondria-targeted therapies in I/R damage.

AB - In recent years, there have been significant advances in our understanding of the functions of mitochondrial complex I other than the generation of energy. These include its role in generation of reactive oxygen species, involvement in the hypoxic tissue response and its possible regulation by nitric oxide (NO) metabolites. In this review, we will focus on the hypoxic conformational change of this mitochondrial enzyme, the so-called active/deactive transition. This conformational change is physiological and relevant to the understanding of certain pathological conditions including, in the cardiovascular system, ischaemia/reperfusion (I/R) damage. We will discuss how complex I can be affected by NO metabolites and will outline some potential mitochondria-targeted therapies in I/R damage.

KW - Journal Article

KW - Review

U2 - 10.1098/rsfs.2016.0104

DO - 10.1098/rsfs.2016.0104

M3 - Review article

VL - 7

SP - 20160104

JO - Interface Focus

T2 - Interface Focus

JF - Interface Focus

SN - 2042-8898

IS - 2

ER -