Modulation of the conformational state of mitochondrial complex I as a target for therapeutic intervention

Alexander Galkin, Salvador Moncada

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

In recent years, there have been significant advances in our understanding of the functions of mitochondrial complex I other than the generation of energy. These include its role in generation of reactive oxygen species, involvement in the hypoxic tissue response and its possible regulation by nitric oxide (NO) metabolites. In this review, we will focus on the hypoxic conformational change of this mitochondrial enzyme, the so-called active/deactive transition. This conformational change is physiological and relevant to the understanding of certain pathological conditions including, in the cardiovascular system, ischaemia/reperfusion (I/R) damage. We will discuss how complex I can be affected by NO metabolites and will outline some potential mitochondria-targeted therapies in I/R damage.

Original languageEnglish
Pages (from-to)20160104
JournalInterface Focus
Volume7
Issue number2
DOIs
Publication statusPublished - 17 Feb 2017

Keywords

  • Journal Article
  • Review

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