Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: Recent developments

Moritz Haneklaus, Luke A.J. O'Neill*, Rebecca C. Coll

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

138 Citations (Scopus)

Abstract

The protein NLRP3 has emerged as a central regulator in the inflammatory process, being implicated directly in hereditary cryopyrinopathies, and indirectly in diseases such as gout, Type 2 diabetes and atherosclerosis. NLRP3 is an important regulator of caspase-1, the enzyme that processes the immature form of IL-1β into the active protein. The control of NLRP3 has therefore become a focus of research with evidence for redox regulation, ubiquitination and regulation by miRNA-223, kinases and calcium all emerging as controllers of NLRP3. As our knowledge expands the prospect for precise pharmacological targeting of NLRP3 will improve and could lead to substantial clinical utility.

Original languageEnglish
Pages (from-to)40-45
Number of pages6
JournalCurrent Opinion in Immunology
Volume25
Issue number1
DOIs
Publication statusPublished - 01 Feb 2013
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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