Molecular diagnostic cytopathology: definitions, scope and clinical utility

Manuel Salto-Tellez, E.S.C. Koay

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Molecular diagnosis is the application of molecular biology techniques and knowledge of the molecular mechanisms of disease to diagnosis, prognostication and treatment of diseases. Although it is not widely used in routine molecular cytological practice, some examples are presented here of the application of molecular techniques to the routine cytopathological diagnosis of solid tumours and lymphoreticular malignancies. The term 'molecular diagnostic cytopathology' is proposed to define the application of molecular diagnosis to cytopathology, and the challenges of the introduction of molecular diagnosis into routine diagnostic histopathology and cytopathology are discussed. Finally, the importance of a combined morphological, immunophenotypic and molecular approach to maintain the diagnostic pathologist at the heart of the clinical decision-making process is emphasized.
Original languageEnglish
Pages (from-to)252-255
Number of pages4
JournalCytopathology
Volume15
Issue number5
Publication statusPublished - Oct 2004

ASJC Scopus subject areas

  • Cell Biology
  • Anatomy

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