Molecular expression and calcium signalling roles of native TRP channels in vascular cells

Donal Melanaphy, Lyudmyla Borisova, Maxim Kustov, Christopher Johnson, Thoedor Burdyga, Alexander Zholos

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)


In the vasculature, multiple members of the TRP-superfamily of non-selective cation channels (NSCCs) are expressed. These channels mediate diverse non-voltage-gated Ca2+-entry pathways and functions, which involve both vascular myocytes and communicating endothelial cells. Here, we provide an overview of recent progress in this area of research and discuss several specific examples of the important roles of vascular TRP channels in calcium signalling and electrophysiological responses. We especially focus on the recently discovered signal transduction mechanisms involving formation of specific complexes between TRP proteins and other better studied proteins that regulate cell calcium homeostasis, such as voltage-gated calcium channels and ryanodine receptors. Finally, we provide an overview of the progress in our understanding of TRPM8, which is known as the principal neuronal cold receptor, expression, localisation and function in the vasculature. We conclude that this channel is likely involved in complex thermal behaviour of blood vessels, better understanding of which is relevant to hypothermic and cardiovascular surgery conditions, therefore further research in this area is needed.

Original languageEnglish
Pages (from-to)195-201
JournalCell Membranes and Free Radical Research
Issue number2
Publication statusPublished - 01 May 2012


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