Molecular mapping the presence of druggable targets in preinvasive and precursor breast lesions: A comprehensive review of biomarkers related to therapeutic interventions

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5 Citations (Scopus)

Abstract

The analysis of clinical breast samples using biomarkers is integral to current breast cancer management. Currently, a limited number of targeted therapies are standard of care in breast cancer treatment. However, these targeted therapies are only suitable for a subset of patients and resistance may occur. Strategies to prevent the occurrence of invasive lesions are required to reduce the morbidity and mortality associated with the development of cancer. In theory, application of targeted therapies to pre-invasive lesions will prevent their progression to invasive lesions with full malignant potential. The diagnostic challenge for pathologists is to make interpretative decisions on early detected pre-invasive lesions. Overall, only a small proportion of these pre-invasive lesions will progress to invasive carcinoma and morphological assessment is an imprecise and subjective means to differentiate histologically identical lesions with varying malignant potential. Therefore differential biomarker analysis in pre-invasive lesions may prevent overtreatment with surgery and provide a predictive indicator of response to therapy. There follows a review of established and emerging potential druggable targets in pre-invasive lesions and correlation with lesion morphology.
Original languageEnglish
Pages (from-to)230-242
JournalBiochimica et biophysica acta
Volume1835
Issue number2
Early online date08 Feb 2013
DOIs
Publication statusPublished - Apr 2013

Bibliographical note

Copyright © 2013 Elsevier B.V. All rights reserved.

Keywords

  • Vascular Endothelial Growth Factor A
  • Precancerous Conditions
  • DNA Topoisomerases, Type II
  • PTEN Phosphohydrolase
  • Receptor, erbB-2
  • DNA-Binding Proteins
  • Humans
  • Antigens, Neoplasm
  • Breast Neoplasms
  • Phosphatidylinositol 3-Kinases
  • Receptors, Progesterone
  • Biological Markers
  • Female
  • Receptors, Estrogen

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Genetics

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