Abstract
The analysis of clinical breast samples using biomarkers is integral to current breast cancer management. Currently, a limited number of targeted therapies are standard of care in breast cancer treatment. However, these targeted therapies are only suitable for a subset of patients and resistance may occur. Strategies to prevent the occurrence of invasive lesions are required to reduce the morbidity and mortality associated with the development of cancer. In theory, application of targeted therapies to pre-invasive lesions will prevent their progression to invasive lesions with full malignant potential. The diagnostic challenge for pathologists is to make interpretative decisions on early detected pre-invasive lesions. Overall, only a small proportion of these pre-invasive lesions will progress to invasive carcinoma and morphological assessment is an imprecise and subjective means to differentiate histologically identical lesions with varying malignant potential. Therefore differential biomarker analysis in pre-invasive lesions may prevent overtreatment with surgery and provide a predictive indicator of response to therapy. There follows a review of established and emerging potential druggable targets in pre-invasive lesions and correlation with lesion morphology.
Original language | English |
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Pages (from-to) | 230-242 |
Journal | Biochimica et biophysica acta |
Volume | 1835 |
Issue number | 2 |
Early online date | 08 Feb 2013 |
DOIs | |
Publication status | Published - Apr 2013 |
Bibliographical note
Copyright © 2013 Elsevier B.V. All rights reserved.Keywords
- Vascular Endothelial Growth Factor A
- Precancerous Conditions
- DNA Topoisomerases, Type II
- PTEN Phosphohydrolase
- Receptor, erbB-2
- DNA-Binding Proteins
- Humans
- Antigens, Neoplasm
- Breast Neoplasms
- Phosphatidylinositol 3-Kinases
- Receptors, Progesterone
- Biological Markers
- Female
- Receptors, Estrogen
ASJC Scopus subject areas
- Oncology
- Cancer Research
- Genetics