Molecular mechanisms of measles virus persistence.

Bert Rima, Paul Duprex

Research output: Contribution to journalLiterature review

83 Citations (Scopus)
245 Downloads (Pure)

Abstract

As measles virus causes subacute sclerosing panencephalitis and measles inclusion body encephalitis due to its ability to establish human persistent infection, without symptoms for the time between the acute infection and the onset of clinical symptoms, it has been the paradigm for a long term persistent as opposed to chronic infection by an RNA virus. We have reviewed the mechanisms of persistence of the virus and discuss specific mutations associated with CNS infection affecting the matrix and fusion protein genes. These are placed in the context of our current understanding of the viral replication cycle. We also consider the proposed mechanisms of persistence of the virus in replicating cell cultures and conclude that no general mechanistic model can be derived from our current state of knowledge. Finally, we indicate how reverse genetics approaches and the use of mouse models with specific knock-out and knock-in modifications can further our understanding of measles virus persistence.
Original languageEnglish
Pages (from-to)132-147
Number of pages16
JournalVirus Research
Volume111
Issue number2
DOIs
Publication statusPublished - Aug 2005

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Virology

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