Molecular modeling of N-terminal domains of NMDA-receptor. Study of ligand binding with N-terminal domains

I.G. Tikhonova; I.I. Baskin; V.A. Palyulin; N.S. Zefirov

Molecular modeling of N-terminal domains of NMDA-receptor. Study of ligand binding with N-terminal domains

I.G. Tikhonova, I.I. Baskin, V.A. Palyulin, N.S. Zefirov

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Using the molecular-graphic complex Sybyl6.7.2, computational construction of spatial models for N-terminal domains (of NR1- and NR2B-subunits) of NMDA-receptor was conducted. On the basis of the constructed models and also CoMFA method the conclusion is made about presence of the binding site for the compounds similar to iphenprodyl in two N-terminal domains of NR1- and NR2B-subunits. The obtained data can be used for constructing new ligands.

Original language	English
Pages (from-to)	549-557
Number of pages	9
Journal	Doklady Akademii nauk SSSR
Volume	397
Issue number	4
Publication status	Published - 01 Jan 2004

Cite this

@article{75cf17e369074c79876864bcd985bb8c,

title = "Molecular modeling of N-terminal domains of NMDA-receptor. Study of ligand binding with N-terminal domains",

abstract = "Using the molecular-graphic complex Sybyl6.7.2, computational construction of spatial models for N-terminal domains (of NR1- and NR2B-subunits) of NMDA-receptor was conducted. On the basis of the constructed models and also CoMFA method the conclusion is made about presence of the binding site for the compounds similar to iphenprodyl in two N-terminal domains of NR1- and NR2B-subunits. The obtained data can be used for constructing new ligands.",

author = "I.G. Tikhonova and I.I. Baskin and V.A. Palyulin and N.S. Zefirov",

year = "2004",

month = jan,

day = "1",

language = "English",

volume = "397",

pages = "549--557",

journal = "Doklady Akademii nauk SSSR",

issn = "0869-5652",

publisher = "Izdatel'stvo Nauka",

number = "4",

}

TY - JOUR

T1 - Molecular modeling of N-terminal domains of NMDA-receptor. Study of ligand binding with N-terminal domains

AU - Tikhonova, I.G.

AU - Baskin, I.I.

AU - Palyulin, V.A.

AU - Zefirov, N.S.

PY - 2004/1/1

Y1 - 2004/1/1

N2 - Using the molecular-graphic complex Sybyl6.7.2, computational construction of spatial models for N-terminal domains (of NR1- and NR2B-subunits) of NMDA-receptor was conducted. On the basis of the constructed models and also CoMFA method the conclusion is made about presence of the binding site for the compounds similar to iphenprodyl in two N-terminal domains of NR1- and NR2B-subunits. The obtained data can be used for constructing new ligands.

AB - Using the molecular-graphic complex Sybyl6.7.2, computational construction of spatial models for N-terminal domains (of NR1- and NR2B-subunits) of NMDA-receptor was conducted. On the basis of the constructed models and also CoMFA method the conclusion is made about presence of the binding site for the compounds similar to iphenprodyl in two N-terminal domains of NR1- and NR2B-subunits. The obtained data can be used for constructing new ligands.

UR - http://www.scopus.com/inward/record.url?partnerID=yv4JPVwI&eid=2-s2.0-12244280186&md5=dee0fcf471426f180be3e33789c1d42f

M3 - Article

AN - SCOPUS:12244280186

SN - 0869-5652

VL - 397

SP - 549

EP - 557

JO - Doklady Akademii nauk SSSR

JF - Doklady Akademii nauk SSSR

IS - 4

ER -

Molecular modeling of N-terminal domains of NMDA-receptor. Study of ligand binding with N-terminal domains

Abstract

Other files and links

Fingerprint

Cite this