Molecular modeling of N-terminal domains of NMDA-receptor. Study of ligand binding with N-terminal domains

I.G. Tikhonova, I.I. Baskin, V.A. Palyulin, N.S. Zefirov

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Using the molecular-graphic complex Sybyl6.7.2, computational construction of spatial models for N-terminal domains (of NR1- and NR2B-subunits) of NMDA-receptor was conducted. On the basis of the constructed models and also CoMFA method the conclusion is made about presence of the binding site for the compounds similar to iphenprodyl in two N-terminal domains of NR1- and NR2B-subunits. The obtained data can be used for constructing new ligands.
Original languageEnglish
Pages (from-to)549-557
Number of pages9
JournalDoklady Akademii nauk SSSR
Volume397
Issue number4
Publication statusPublished - 01 Jan 2004

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