Molecular pathomechanisms of Alzheimer's disease

B. Penke; Z. Datki; C. Hetényi; Z. Molnár; I. Lengyel; K. Soós; M. Zarándi

doi:10.1016/j.theochem.2003.08.074

Molecular pathomechanisms of Alzheimer's disease

B. Penke^*, Z. Datki, C. Hetényi, Z. Molnár, I. Lengyel, K. Soós, M. Zarándi

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

β-Amyloids are neurotoxic compounds produced in the brain and cause Alzheimer-type senile dementia. Their toxicity is in good correlation with their aggregation properties. Short peptide fragments of β-amyloid prevent Aβ-toxicity, probably by binding on the Aβ-aggregate surface.

Original language	English
Pages (from-to)	507-513
Number of pages	7
Journal	Journal of Molecular Structure: THEOCHEM
Volume	666-667
DOIs	https://doi.org/10.1016/j.theochem.2003.08.074
Publication status	Published - 29 Dec 2003
Externally published	Yes

Keywords

β-Amyloid
Alzheimer's disease
Neurodegeneration
Neuroprotection

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Computational Theory and Mathematics
Atomic and Molecular Physics, and Optics

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10.1016/j.theochem.2003.08.074

Cite this

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title = "Molecular pathomechanisms of Alzheimer's disease",

abstract = "β-Amyloids are neurotoxic compounds produced in the brain and cause Alzheimer-type senile dementia. Their toxicity is in good correlation with their aggregation properties. Short peptide fragments of β-amyloid prevent Aβ-toxicity, probably by binding on the Aβ-aggregate surface.",

keywords = "β-Amyloid, Alzheimer's disease, Neurodegeneration, Neuroprotection",

author = "B. Penke and Z. Datki and C. Het{\'e}nyi and Z. Moln{\'a}r and I. Lengyel and K. So{\'o}s and M. Zar{\'a}ndi",

year = "2003",

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doi = "10.1016/j.theochem.2003.08.074",

language = "English",

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TY - JOUR

T1 - Molecular pathomechanisms of Alzheimer's disease

AU - Penke, B.

AU - Datki, Z.

AU - Hetényi, C.

AU - Molnár, Z.

AU - Lengyel, I.

AU - Soós, K.

AU - Zarándi, M.

PY - 2003/12/29

Y1 - 2003/12/29

N2 - β-Amyloids are neurotoxic compounds produced in the brain and cause Alzheimer-type senile dementia. Their toxicity is in good correlation with their aggregation properties. Short peptide fragments of β-amyloid prevent Aβ-toxicity, probably by binding on the Aβ-aggregate surface.

AB - β-Amyloids are neurotoxic compounds produced in the brain and cause Alzheimer-type senile dementia. Their toxicity is in good correlation with their aggregation properties. Short peptide fragments of β-amyloid prevent Aβ-toxicity, probably by binding on the Aβ-aggregate surface.

KW - β-Amyloid

KW - Alzheimer's disease

KW - Neurodegeneration

KW - Neuroprotection

UR - http://www.scopus.com/inward/record.url?scp=1642492908&partnerID=8YFLogxK

U2 - 10.1016/j.theochem.2003.08.074

DO - 10.1016/j.theochem.2003.08.074

M3 - Article

AN - SCOPUS:1642492908

SN - 0166-1280

VL - 666-667

SP - 507

EP - 513

JO - Journal of Molecular Structure: THEOCHEM

JF - Journal of Molecular Structure: THEOCHEM

ER -

Molecular pathomechanisms of Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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