Molecular structure, regulation and subcellular distribution of mu opioid receptors during postnatal development

M. Szucs; H. A. Oktem; V. Szuts; I. Lengyel; G. Toth; C. J. Coscia; M. Wollemann

Molecular structure, regulation and subcellular distribution of mu opioid receptors during postnatal development

M. Szucs, H. A. Oktem, V. Szuts, I. Lengyel, G. Toth, C. J. Coscia, M. Wollemann

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Brains of mature and neonatal (P-3) rats were subjected to subcellular fractionation. Light membranes of P-3 contained more [³H]DAGO binding sites (40% of total μ sites vs 16% in adult) with greater sensitivity to GTP. Affinity labelling with [³H]DAGOCK revealed that the major subunit has a molecular weight of about 50 kDa in the synaptic as well as light membrane fractions.

Original language	English
Title of host publication	New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914
Editors	J.M. Van Ree, A.H. Mulder, V.M. Wiegant, T.B. Van Wimersma Greidanus, J.M. Van Ree, A.H. Mulder, V.M. Wiegant, T.B. Van Wimersma Greidanus
Publisher	Elsevier Science Publishers B.V.
Pages	250
Number of pages	1
ISBN (Print)	044481213X
Publication status	Published - 1990
Externally published	Yes
Event	The International Narcotics Research Conference - Duration: 08 Jul 1989 → 13 Jul 1989

Conference

Conference	The International Narcotics Research Conference
Period	08/07/1989 → 13/07/1989

ASJC Scopus subject areas

Medicine(all)

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Szucs, M., Oktem, H. A., Szuts, V., Lengyel, I., Toth, G., Coscia, C. J., & Wollemann, M. (1990). Molecular structure, regulation and subcellular distribution of mu opioid receptors during postnatal development. In J. M. Van Ree, A. H. Mulder, V. M. Wiegant, T. B. Van Wimersma Greidanus, J. M. Van Ree, A. H. Mulder, V. M. Wiegant, & T. B. Van Wimersma Greidanus (Eds.), New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914 (pp. 250). Elsevier Science Publishers B.V..

Szucs, M. ; Oktem, H. A. ; Szuts, V. ; Lengyel, I. ; Toth, G. ; Coscia, C. J. ; Wollemann, M. / Molecular structure, regulation and subcellular distribution of mu opioid receptors during postnatal development. New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914. editor / J.M. Van Ree ; A.H. Mulder ; V.M. Wiegant ; T.B. Van Wimersma Greidanus ; J.M. Van Ree ; A.H. Mulder ; V.M. Wiegant ; T.B. Van Wimersma Greidanus. Elsevier Science Publishers B.V., 1990. pp. 250

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title = "Molecular structure, regulation and subcellular distribution of mu opioid receptors during postnatal development",

abstract = "Brains of mature and neonatal (P-3) rats were subjected to subcellular fractionation. Light membranes of P-3 contained more [3H]DAGO binding sites (40% of total μ sites vs 16% in adult) with greater sensitivity to GTP. Affinity labelling with [3H]DAGOCK revealed that the major subunit has a molecular weight of about 50 kDa in the synaptic as well as light membrane fractions.",

author = "M. Szucs and Oktem, {H. A.} and V. Szuts and I. Lengyel and G. Toth and Coscia, {C. J.} and M. Wollemann",

year = "1990",

language = "English",

isbn = "044481213X",

pages = "250",

editor = "{Van Ree}, J.M. and A.H. Mulder and V.M. Wiegant and {Van Wimersma Greidanus}, T.B. and {Van Ree}, J.M. and A.H. Mulder and V.M. Wiegant and {Van Wimersma Greidanus}, T.B.",

booktitle = "New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914",

publisher = "Elsevier Science Publishers B.V.",

note = "The International Narcotics Research Conference ; Conference date: 08-07-1989 Through 13-07-1989",

}

Szucs, M, Oktem, HA, Szuts, V, Lengyel, I, Toth, G, Coscia, CJ & Wollemann, M 1990, Molecular structure, regulation and subcellular distribution of mu opioid receptors during postnatal development. in JM Van Ree, AH Mulder, VM Wiegant, TB Van Wimersma Greidanus, JM Van Ree, AH Mulder, VM Wiegant & TB Van Wimersma Greidanus (eds), New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914. Elsevier Science Publishers B.V., pp. 250, The International Narcotics Research Conference, 08/07/1989.

Molecular structure, regulation and subcellular distribution of mu opioid receptors during postnatal development. / Szucs, M.; Oktem, H. A.; Szuts, V.; Lengyel, I.; Toth, G.; Coscia, C. J.; Wollemann, M.

New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914. ed. / J.M. Van Ree; A.H. Mulder; V.M. Wiegant; T.B. Van Wimersma Greidanus; J.M. Van Ree; A.H. Mulder; V.M. Wiegant; T.B. Van Wimersma Greidanus. Elsevier Science Publishers B.V., 1990. p. 250.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Molecular structure, regulation and subcellular distribution of mu opioid receptors during postnatal development

AU - Szucs, M.

AU - Oktem, H. A.

AU - Szuts, V.

AU - Lengyel, I.

AU - Toth, G.

AU - Coscia, C. J.

AU - Wollemann, M.

PY - 1990

Y1 - 1990

N2 - Brains of mature and neonatal (P-3) rats were subjected to subcellular fractionation. Light membranes of P-3 contained more [3H]DAGO binding sites (40% of total μ sites vs 16% in adult) with greater sensitivity to GTP. Affinity labelling with [3H]DAGOCK revealed that the major subunit has a molecular weight of about 50 kDa in the synaptic as well as light membrane fractions.

AB - Brains of mature and neonatal (P-3) rats were subjected to subcellular fractionation. Light membranes of P-3 contained more [3H]DAGO binding sites (40% of total μ sites vs 16% in adult) with greater sensitivity to GTP. Affinity labelling with [3H]DAGOCK revealed that the major subunit has a molecular weight of about 50 kDa in the synaptic as well as light membrane fractions.

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M3 - Conference contribution

AN - SCOPUS:0025084123

SN - 044481213X

SP - 250

BT - New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914

A2 - Van Ree, J.M.

A2 - Mulder, A.H.

A2 - Wiegant, V.M.

A2 - Van Wimersma Greidanus, T.B.

A2 - Van Ree, J.M.

A2 - Mulder, A.H.

A2 - Wiegant, V.M.

A2 - Van Wimersma Greidanus, T.B.

PB - Elsevier Science Publishers B.V.

T2 - The International Narcotics Research Conference

Y2 - 8 July 1989 through 13 July 1989

ER -

Szucs M, Oktem HA, Szuts V, Lengyel I, Toth G, Coscia CJ et al. Molecular structure, regulation and subcellular distribution of mu opioid receptors during postnatal development. In Van Ree JM, Mulder AH, Wiegant VM, Van Wimersma Greidanus TB, Van Ree JM, Mulder AH, Wiegant VM, Van Wimersma Greidanus TB, editors, New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914. Elsevier Science Publishers B.V. 1990. p. 250