Molecular structure, regulation and subcellular distribution of mu opioid receptors during postnatal development

M. Szucs, H. A. Oktem, V. Szuts, I. Lengyel, G. Toth, C. J. Coscia, M. Wollemann

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Brains of mature and neonatal (P-3) rats were subjected to subcellular fractionation. Light membranes of P-3 contained more [3H]DAGO binding sites (40% of total μ sites vs 16% in adult) with greater sensitivity to GTP. Affinity labelling with [3H]DAGOCK revealed that the major subunit has a molecular weight of about 50 kDa in the synaptic as well as light membrane fractions.

Original languageEnglish
Title of host publicationNew leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914
EditorsJ.M. Van Ree, A.H. Mulder, V.M. Wiegant, T.B. Van Wimersma Greidanus, J.M. Van Ree, A.H. Mulder, V.M. Wiegant, T.B. Van Wimersma Greidanus
PublisherElsevier Science Publishers B.V.
Pages250
Number of pages1
ISBN (Print)044481213X
Publication statusPublished - 1990
Externally publishedYes
EventThe International Narcotics Research Conference -
Duration: 08 Jul 198913 Jul 1989

Conference

ConferenceThe International Narcotics Research Conference
Period08/07/198913/07/1989

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Szucs, M., Oktem, H. A., Szuts, V., Lengyel, I., Toth, G., Coscia, C. J., & Wollemann, M. (1990). Molecular structure, regulation and subcellular distribution of mu opioid receptors during postnatal development. In J. M. Van Ree, A. H. Mulder, V. M. Wiegant, T. B. Van Wimersma Greidanus, J. M. Van Ree, A. H. Mulder, V. M. Wiegant, & T. B. Van Wimersma Greidanus (Eds.), New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914 (pp. 250). Elsevier Science Publishers B.V..