Abstract
A novel approach towards recognition of sulfonylureas based on a polymerisable ion pair is presented. A solution association constant >105 M−1 between the model target glibenclamide and 4-vinylbenzyltrimethylammonium methacrylate is measured, and the formation of 1 : 1 complexes verified. Subsequently prepared stoichiometrically imprinted polymers exhibit exceptionally high affinity and binding capacity for glibenclamide, owing to synergistic binding of both the neutral and deprotonated form of the drug by the ion pair monomer. The polymers are applied to the selective extraction of glibenclamide from blood serum samples, achieving recoveries of up to 98% and demonstrating excellent long-term stability, negating the need for regular sorbent regeneration.
Original language | English |
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Pages (from-to) | 14212-14220 |
Number of pages | 9 |
Journal | RSC Advances |
Volume | 8 |
Early online date | 17 Apr 2018 |
DOIs | |
Publication status | Published - 17 Apr 2018 |
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Dive into the research topics of 'Molecular ‘traps’ for sulfonylureas prepared using polymerisable ion-pair receptors'. Together they form a unique fingerprint.Student Theses
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Ion-pair based Molecular Imprinted Polymers for bioanalysis and sustainable use of organocatalysts
Author: Pessagno, F., Jul 2020Supervisor: Manesiotis, P. (Supervisor) & Muldoon, M. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy