Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 14212-14220 |
| Number of pages | 9 |
| Journal | RSC Advances |
| Volume | 8 |
| Early online date | 17 Apr 2018 |
| DOIs | |
| Publication status | Published - 17 Apr 2018 |
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Molecular ‘traps’ for sulfonylureas prepared using polymerisable ion-pair receptors. / Pessagno, Federica; Hasanah, Aliya; Manesiotis, Panagiotis.
In: RSC Advances, Vol. 8, 17.04.2018, p. 14212-14220.Research output: Contribution to journal › Article
TY - JOUR
T1 - Molecular ‘traps’ for sulfonylureas prepared using polymerisable ion-pair receptors
AU - Pessagno, Federica
AU - Hasanah, Aliya
AU - Manesiotis, Panagiotis
PY - 2018/4/17
Y1 - 2018/4/17
N2 - A novel approach towards recognition of sulfonylureas based on a polymerisable ion pair is presented. A solution association constant >105 M−1 between the model target glibenclamide and 4-vinylbenzyltrimethylammonium methacrylate is measured, and the formation of 1 : 1 complexes verified. Subsequently prepared stoichiometrically imprinted polymers exhibit exceptionally high affinity and binding capacity for glibenclamide, owing to synergistic binding of both the neutral and deprotonated form of the drug by the ion pair monomer. The polymers are applied to the selective extraction of glibenclamide from blood serum samples, achieving recoveries of up to 98% and demonstrating excellent long-term stability, negating the need for regular sorbent regeneration.
AB - A novel approach towards recognition of sulfonylureas based on a polymerisable ion pair is presented. A solution association constant >105 M−1 between the model target glibenclamide and 4-vinylbenzyltrimethylammonium methacrylate is measured, and the formation of 1 : 1 complexes verified. Subsequently prepared stoichiometrically imprinted polymers exhibit exceptionally high affinity and binding capacity for glibenclamide, owing to synergistic binding of both the neutral and deprotonated form of the drug by the ion pair monomer. The polymers are applied to the selective extraction of glibenclamide from blood serum samples, achieving recoveries of up to 98% and demonstrating excellent long-term stability, negating the need for regular sorbent regeneration.
U2 - 10.1039/c8ra01135d
DO - 10.1039/c8ra01135d
M3 - Article
VL - 8
SP - 14212
EP - 14220
JO - RSC Advances
JF - RSC Advances
SN - 2046-2069
ER -