Moving towards a Treatable Traits model of care for the management of obstructive airways diseases

Alvar Agusti, Neil Barnes, Alvaro A Cruz, Peter G Gibson, Liam G Heaney, Hiromasa Inoue, David Leather, Fernando J Martinez, Vanessa M McDonald, John Oppenheimer, Alberto Papi, Ian D Pavord, Mike Thomas, Samantha Walker, Louisa Yates

Research output: Contribution to journalArticlepeer-review

Abstract

Asthma and chronic obstructive pulmonary disease (COPD) are two prevalent chronic airways diseases. Both are complex and heterogeneous. Traditionally, clinical guidelines have advocated a stepwise approach to pharmacotherapy of asthma and COPD, but there is increasing realization that both require a more personalized and precise management approach. To this end, a management strategy based on the so-called Treatable Traits has been proposed. Emerging evidence suggests that this model improves relevant outcomes in patients with chronic airway diseases but further research is needed to guide implementation. This review discusses the challenges, opportunities, and hurdles that its implementation will have to face.
Original languageEnglish
Article number106572
JournalRespiratory medicine
Volume187
Early online date13 Aug 2021
DOIs
Publication statusPublished - 01 Oct 2021

Keywords

  • COPD
  • Biomarkers
  • Asthma
  • Targeted therapy

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