Multi-walled carbon nanotubes-based magnetic solid-phase extraction for the determination of zearalenone and its derivatives in maize by ultra-high performance liquid chromatography-tandem mass spectrometry

Zheng Han, Keqiu Jiang, Zhichen Fan, José Diana Di Mavungu, Maofeng Dong, Wenbo Guo, Kai Fan, Katrina Campbell, Zhihui Zhao*, Yongjiang Wu

*Corresponding author for this work

Research output: Contribution to journalArticle

27 Citations (Scopus)
234 Downloads (Pure)

Abstract

A simple and rapid magnetic solid-phase extraction (M-SPE) procedure using multi-walled carbon nanotube-magnetic nanoparticles (MWCNT-MNPs) as sorbents was established for purification of zearalenone (ZEA), α-zearalenol (α-ZOL), β-zearalenol (β-ZOL), zearalanone (ZAN), α-zearalanol (α-ZAL) and β-zearalanol (β-ZAL) in maize. The main parameters affecting the clean-up efficiency were thoroughly investigated, and high purification efficiencies for all analytes were obtained. The resulting MWCNT-MNP-ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was validated for maize samples. The matrix effects were greatly minimized using the M-SPE approach, with signal suppression/enhancement values decreased from 69.9–127.6% to 92.1–103.8%. Consequently, complex matrix-matched calibration curves were not necessary and the calibrations constructed in acetonitrile could be applied for accurate quantification of the targeted mycotoxins in real samples. The average recoveries ranged from 75.8 to 104.1% and the inter- and intra-day precision values expressed as RSDs, were all lower than 14%. Limits of detection and quantification were in the range of 0.03–0.04 and 0.07–0.10 μg/kg, respectively. The analytical performance of the developed method was also successfully evaluated with maize samples, and this method was proved to be a powerful tool for monitoring ZEA and its derivatives in maize.

Original languageEnglish
Pages (from-to)177-184
Number of pages8
JournalFood Control
Volume79
Early online date29 Mar 2017
DOIs
Publication statusPublished - 01 Sep 2017

Keywords

  • Magnetic solid-phase extraction
  • Maize
  • Multi-walled carbon nanotubes
  • Ultra-high performance liquid chromatography-tandem mass spectrometry
  • Zearalenone and its derivatives

ASJC Scopus subject areas

  • Biotechnology
  • Food Science

Fingerprint Dive into the research topics of 'Multi-walled carbon nanotubes-based magnetic solid-phase extraction for the determination of zearalenone and its derivatives in maize by ultra-high performance liquid chromatography-tandem mass spectrometry'. Together they form a unique fingerprint.

  • Cite this