Multicenter linkage study of schizophrenia loci on chromosome 22q

B. J. Mowry*, P. A. Holmans, A. E. Pulver, P. V. Gejman, B. Riley, N. M. Williams, C. Laurent, S. G. Schwab, D. B. Wildenauer, S. Bauché, M. J. Owen, B. Wormley, A. R. Sanders, G. Nestadt, K. Y. Liang, J. Duan, R. Ribble, N. Norton, S. Soubigou, W. MaierK. R. Ewen-White, N. DeMarchi, B. Carpenter, D. Walsh, H. Williams, M. Jay, M. Albus, D. A. Nertney, G. Papadimitriou, A. O'Neill, M. C. O'Donovan, J. F. Deleuze, F. B. Lerer, D. Dikeos, K. S. Kendler, J. Mallet, J. M. Silverman, R. R. Crowe, D. F. Levinson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

55 Citations (Scopus)

Abstract

The hypothesis of the existence of one or more schizophrenia susceptibility loci on chromosome 22q is supported by reports of genetic linkage and association, meta-analyses of linkage, and the observation of elevated risk for psychosis in people with velocardiofacial syndrome, caused by 22q11 microdeletions. We tested this hypothesis by evaluating 10 microsatellite markers spanning 22q in a multicenter sample of 779 pedigrees. We also incorporated age at onset and sex into the analysis as covariates. No significant evidence for linkage to schizophrenia or for linkage associated with earlier age at onset, gender, or heterogeneity across sites was observed. We interpret these findings to mean that the population-wide effects of putative 22q schizophrenia susceptibility loci are too weak to detect with linkage analysis even in large samples.

Original languageEnglish
Pages (from-to)784-795
Number of pages12
JournalMolecular Psychiatry
Volume9
Issue number8
DOIs
Publication statusPublished - Aug 2004

Bibliographical note

Funding Information:
We gratefully acknowledge participation of family members. Supported by NIMH Grants KO2-01207 and K24-MH64197 (DFL); the Australian NHMRC Grants 33505 and 35016, and Queensland Department of Health (BJM); NIMH Grant MH61602 (DFL, CL, BR, AEP, PVG, DBW, MJO); NIMH Grants MH 41953, 52537, and 45390 (BR and KSK); the UK Medical Research Council (MJO, MO’D); Deutsche For-schungsgemeinschaft Grant SFB 400 (DBW, WM); the German–Israeli Foundation for Scientific Research (BL, DBW); the NIMH Intramural Program and the Brain Research Foundation, University of Chicago (PVG); NIMH Grant RO1-MH57314 (AEP); and CNRS and Aventis Pharma SA (JM, CL). Specimens from the NIMH Schizophrenia Genetics Initiative (NIMH SGI) were used in this study. Data and biomaterials were collected in three projects that participated in the NIMH SGI. From 1991 to 1997, the principal investigators and coinvestigators were Harvard University (Grant U01 MH46318) (MT Tsuang, S Faraone, and J Pepple); Washington University, St Louis (Grant U01 MH46276) (CR Cloninger, T Reich, and D Svrakic); and Columbia University (Grant U01 MH46289) (C Kaufmann, D Malaspina, and J Harkavy Friedman).

Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.

Keywords

  • Chromosomes, human, pair 22
  • Genetics, medical
  • Genetics, molecular
  • Linkage (genetics)
  • Schizophrenia

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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