Multicharge Zwitterionic Molecules: Hydration, Kosmotropicity and Anti-fouling Potential

Gaelle Level, Jiaxin Zhang, John Brown, Oliver Hammond, Brian Hannigan, Lorenzo Stella, Peter Nockemann, Marijana Blesic

Research output: Contribution to journalArticle

Abstract

This manuscript presents a comparative study of the physico-chemical behaviour of sulfobetaine-type single and double zwitterions and zwitterionic salts, and structurally similar mono-and di-cationic tetraalkylammonium salts in aqueous solutions. The study includes experimental determination of the density and viscosity of highly diluted aqueous solutions with derivation of the Jones-Dole viscosity B-coefficient, partial molal volumes at infinite dilution, and hydration numbers. The study also examines the effects of addition of the salts on the surface tension of cationic and anionic surfactants, upper critical solution temperature of a non-ionic surfactant, solubility of amino acids, and stability of a protein. The experimental investigation was performed taking a broad bottom-up approach with the aim to elucidate the effect of molecular architecture and charge (two versus four) on the degree of surface hydration of a molecule, kosmotropicity, and interactions with charged and hydrophilic/hydrophobic surfaces - all-important characteristics which define ability of a functional group to resist protein attachment. The novel multicharged zwitterionic materials have exhibited superior qualities, thus paving the way to development of a new platform in design of hydrophilic and anti-fouling surfaces by employing the four-charge bearing molecular motifs.
Original languageEnglish
JournalJournal of Colloid and Interface Science
Early online date05 Dec 2019
DOIs
Publication statusPublished - 18 Dec 2019

Fingerprint

Fouling
Hydration
Salts
Molecules
Bearings (structural)
Viscosity
Proteins
Anionic surfactants
Cationic surfactants
Nonionic surfactants
Functional groups
Dilution
Surface tension
Amino acids
Solubility
Amino Acids
Temperature

Keywords

  • aqueous solution, zwitterion, zwitterionic salt, tetraalkylammonium, surface tension, viscosity, density, Jones-Dole viscosity B-coefficient, protein, solubility, amino acid

Cite this

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abstract = "This manuscript presents a comparative study of the physico-chemical behaviour of sulfobetaine-type single and double zwitterions and zwitterionic salts, and structurally similar mono-and di-cationic tetraalkylammonium salts in aqueous solutions. The study includes experimental determination of the density and viscosity of highly diluted aqueous solutions with derivation of the Jones-Dole viscosity B-coefficient, partial molal volumes at infinite dilution, and hydration numbers. The study also examines the effects of addition of the salts on the surface tension of cationic and anionic surfactants, upper critical solution temperature of a non-ionic surfactant, solubility of amino acids, and stability of a protein. The experimental investigation was performed taking a broad bottom-up approach with the aim to elucidate the effect of molecular architecture and charge (two versus four) on the degree of surface hydration of a molecule, kosmotropicity, and interactions with charged and hydrophilic/hydrophobic surfaces - all-important characteristics which define ability of a functional group to resist protein attachment. The novel multicharged zwitterionic materials have exhibited superior qualities, thus paving the way to development of a new platform in design of hydrophilic and anti-fouling surfaces by employing the four-charge bearing molecular motifs.",
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Multicharge Zwitterionic Molecules: Hydration, Kosmotropicity and Anti-fouling Potential. / Level, Gaelle; Zhang, Jiaxin; Brown, John; Hammond, Oliver; Hannigan, Brian; Stella, Lorenzo; Nockemann, Peter; Blesic, Marijana.

In: Journal of Colloid and Interface Science, 18.12.2019.

Research output: Contribution to journalArticle

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T1 - Multicharge Zwitterionic Molecules: Hydration, Kosmotropicity and Anti-fouling Potential

AU - Level, Gaelle

AU - Zhang, Jiaxin

AU - Brown, John

AU - Hammond, Oliver

AU - Hannigan, Brian

AU - Stella, Lorenzo

AU - Nockemann, Peter

AU - Blesic, Marijana

PY - 2019/12/18

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AB - This manuscript presents a comparative study of the physico-chemical behaviour of sulfobetaine-type single and double zwitterions and zwitterionic salts, and structurally similar mono-and di-cationic tetraalkylammonium salts in aqueous solutions. The study includes experimental determination of the density and viscosity of highly diluted aqueous solutions with derivation of the Jones-Dole viscosity B-coefficient, partial molal volumes at infinite dilution, and hydration numbers. The study also examines the effects of addition of the salts on the surface tension of cationic and anionic surfactants, upper critical solution temperature of a non-ionic surfactant, solubility of amino acids, and stability of a protein. The experimental investigation was performed taking a broad bottom-up approach with the aim to elucidate the effect of molecular architecture and charge (two versus four) on the degree of surface hydration of a molecule, kosmotropicity, and interactions with charged and hydrophilic/hydrophobic surfaces - all-important characteristics which define ability of a functional group to resist protein attachment. The novel multicharged zwitterionic materials have exhibited superior qualities, thus paving the way to development of a new platform in design of hydrophilic and anti-fouling surfaces by employing the four-charge bearing molecular motifs.

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