Multifaceted control of mRNA translation machinery in cancer

Lilas Alboushi, Angela Hackett, Parisa Naeli, Mostafa Balkhti, Seyed Mehdi Jafarnejad

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The mRNA translation machinery is tightly regulated through several, at times overlapping, mechanisms that modulate its efficiency and accuracy. Due to their fast rate of growth and metabolism, cancer cells require an excessive amount of mRNA translation and protein synthesis. However, unfavorable conditions, such as hypoxia, amino acid starvation, and oxidative stress, which are abundant in cancer, as well as many anti-cancer treatments inhibit mRNA translation. Cancer cells adapt to the various internal and environmental stresses by employing specialised transcript-specific translation to survive and gain a proliferative advantage. We will highlight the major signaling pathways and mechanisms of translation that regulate the global or mRNA-specific translation in response to the intra- or extra-cellular signals and stresses that are key components in the process of tumourigenesis.

Original languageEnglish
Article number110037
Number of pages24
JournalCellular Signalling
Early online date08 May 2021
Publication statusPublished - Aug 2021

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Copyright © 2021. Published by Elsevier Inc.


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