Multimodal imaging in type 2 idiopathic macular telangiectasia

Ferenc B Sallo, Irene Leung, Traci E Clemons, Tunde Peto, Alan C Bird, Daniel Pauleikhoff

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

BACKGROUND: Macular telangiectasia Type 2 is a bilateral, progressive potentially blinding retinal disease characterized by both vascular and neurodegenerative signs that have been documented using different imaging techniques. The correlation between macular telangiectasia Type 2 signs from various imaging modalities is unknown. Our aim was to investigate the relationship of various macular telangiectasia Type 2 signs using fundus fluorescein angiography, optical coherence tomography and dual-wavelength autofluorescence images.

METHODS: Participants were selected from the macular telangiectasia Type 2 Natural History Observation Study, based on a confirmed diagnosis and the availability of images. Signs in fundus fluorescein angiography, dual-wavelength autofluorescence, and optical coherence tomography images were graded according to standardized categories, and agreement among the multimodel imaging was assessed statistically.

RESULTS: One hundred and ninety-one eyes of 96 patients were examined. Significant correlations were found between early and late fundus fluorescein angiography (ρ = 0.82, P < 0.0001), luteal pigment loss and early/late fundus fluorescein angiography signs (ρ = 0.52, P < 0.0001 and ρ = 0.62, P < 0.0001, respectively), inner and outer segment break length and pigment loss (Class 1 vs. 2/3, P < 0.0001; Class 2 vs. 3, P = 0.04). Correlation between pigment loss and retinal spaces/atrophic retinal restructuring was fair (κ = 0.25-0.33). Bilateral symmetry was slight to substantial (κ = 0.18-0.62).

CONCLUSION: Our data demonstrate the relative extent of neurodegenerative and vascular signs; it may be useful for designing systems for staging disease severity using multimodal imaging and may also provide clues to the pathogenesis of the disease.

Original languageEnglish
Pages (from-to)742-749
Number of pages8
JournalRetina (Philadelphia, Pa.)
Volume35
Issue number4
DOIs
Publication statusPublished - Apr 2015

Keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Fluorescein Angiography
  • Humans
  • Male
  • Middle Aged
  • Multimodal Imaging
  • Optical Imaging
  • Phenotype
  • Prospective Studies
  • Retinal Telangiectasis
  • Retinal Vessels
  • Tomography, Optical Coherence
  • Journal Article
  • Multicenter Study
  • Observational Study
  • Research Support, Non-U.S. Gov't

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  • Cite this

    Sallo, F. B., Leung, I., Clemons, T. E., Peto, T., Bird, A. C., & Pauleikhoff, D. (2015). Multimodal imaging in type 2 idiopathic macular telangiectasia. Retina (Philadelphia, Pa.), 35(4), 742-749. https://doi.org/10.1097/IAE.0000000000000365