Abstract
Rheumatoid arthritis (RA) is an inflammatory joint disease often affecting the hands, which if untreated causes disability. Diffuse optical tomography (DOT) provides information about underlying functional properties of biological tissue. To detect pathophysiological changes in inflamed RA joints, a good understanding of baseline values for healthy subjects is first required. Finger joints from healthy subjects were imaged using a non-contact, multispectral,
continuous wave DOT system, recovering physiological parameters of oxygen saturation, total haemoglobin, water concentration and scatter amplitude. Reconstructed values across the cohort demonstrated good consistency between finger joints from the same participant, with greater variation seen between subjects.
continuous wave DOT system, recovering physiological parameters of oxygen saturation, total haemoglobin, water concentration and scatter amplitude. Reconstructed values across the cohort demonstrated good consistency between finger joints from the same participant, with greater variation seen between subjects.
Original language | English |
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Pages (from-to) | 1445-1460 |
Journal | Biomedical Optics Express |
Volume | 9 |
Issue number | 4 |
Early online date | 02 Mar 2018 |
DOIs | |
Publication status | Published - 01 Apr 2018 |
Externally published | Yes |