Myocardial expression of the endothelin system in endotoxin-treated rats.

J.P. Spiers; A. Dorman; J.D. Allen; Elizabeth Kelso; Barbara McDermott

doi:10.1097/00005344-200108000-00012

Myocardial expression of the endothelin system in endotoxin-treated rats.

J.P. Spiers, A. Dorman, J.D. Allen, Elizabeth Kelso, Barbara McDermott

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Although circulating plasma levels of endothelin (ET)-1 are elevated in endotoxemia, little is known about the myocardial expression of the ET system in endotoxic shock. We assessed the temporal mRNA expression pattern of key components of the ET system (pre-pro ET (ppET) -1, -2, ET-converting enzyme-1, ETA and ETB receptors) by reverse transcription polymerase chain reaction in a rat model of early endotoxic shock. Lipopolysaccharide (5 mg/kg, i.p.) caused a transient increase (p 12-fold increase; p

Original language	English
Pages (from-to)	259-267
Number of pages	9
Journal	Journal of Cardiovascular Pharmacology
Volume	38(2)
Issue number	2
DOIs	https://doi.org/10.1097/00005344-200108000-00012
Publication status	Published - Aug 2001

ASJC Scopus subject areas

Pharmacology
Cardiology and Cardiovascular Medicine

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10.1097/00005344-200108000-00012

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abstract = "Although circulating plasma levels of endothelin (ET)-1 are elevated in endotoxemia, little is known about the myocardial expression of the ET system in endotoxic shock. We assessed the temporal mRNA expression pattern of key components of the ET system (pre-pro ET (ppET) -1, -2, ET-converting enzyme-1, ETA and ETB receptors) by reverse transcription polymerase chain reaction in a rat model of early endotoxic shock. Lipopolysaccharide (5 mg/kg, i.p.) caused a transient increase (p 12-fold increase; p",

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AU - Allen, J.D.

AU - Kelso, Elizabeth

AU - McDermott, Barbara

PY - 2001/8

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AB - Although circulating plasma levels of endothelin (ET)-1 are elevated in endotoxemia, little is known about the myocardial expression of the ET system in endotoxic shock. We assessed the temporal mRNA expression pattern of key components of the ET system (pre-pro ET (ppET) -1, -2, ET-converting enzyme-1, ETA and ETB receptors) by reverse transcription polymerase chain reaction in a rat model of early endotoxic shock. Lipopolysaccharide (5 mg/kg, i.p.) caused a transient increase (p 12-fold increase; p

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Myocardial expression of the endothelin system in endotoxin-treated rats.

Abstract

ASJC Scopus subject areas

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