Myocardial expression of the endothelin system in endotoxin-treated rats.

J.P. Spiers, A. Dorman, J.D. Allen, Elizabeth Kelso, Barbara McDermott

Research output: Contribution to journalArticle

3 Citations (Scopus)


Although circulating plasma levels of endothelin (ET)-1 are elevated in endotoxemia, little is known about the myocardial expression of the ET system in endotoxic shock. We assessed the temporal mRNA expression pattern of key components of the ET system (pre-pro ET (ppET) -1, -2, ET-converting enzyme-1, ETA and ETB receptors) by reverse transcription polymerase chain reaction in a rat model of early endotoxic shock. Lipopolysaccharide (5 mg/kg, i.p.) caused a transient increase (p 12-fold increase; p
Original languageEnglish
Pages (from-to)259-267
Number of pages9
JournalJournal of Cardiovascular Pharmacology
Issue number2
Publication statusPublished - Aug 2001

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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