Abstract
Although circulating plasma levels of endothelin (ET)-1 are elevated in endotoxemia, little is known about the myocardial expression of the ET system in endotoxic shock. We assessed the temporal mRNA expression pattern of key components of the ET system (pre-pro ET (ppET) -1, -2, ET-converting enzyme-1, ETA and ETB receptors) by reverse transcription polymerase chain reaction in a rat model of early endotoxic shock. Lipopolysaccharide (5 mg/kg, i.p.) caused a transient increase (p 12-fold increase; p
| Original language | English |
|---|---|
| Pages (from-to) | 259-267 |
| Number of pages | 9 |
| Journal | Journal of Cardiovascular Pharmacology |
| Volume | 38(2) |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Aug 2001 |
ASJC Scopus subject areas
- Pharmacology
- Cardiology and Cardiovascular Medicine
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Spiers, J. P., Dorman, A., Allen, J. D., Kelso, E., & McDermott, B. (2001). Myocardial expression of the endothelin system in endotoxin-treated rats. Journal of Cardiovascular Pharmacology, 38(2)(2), 259-267. https://doi.org/10.1097/00005344-200108000-00012