Nanodosimetric effects of gold nanoparticles in megavoltage radiation therapy

Stephen McMahon, Wendy Hyland, M.F. Muir, Jonathan Coulter, S. Jain, Karl Butterworth, Giuseppe Schettino, Glenn Dickson, Alan Hounsell, Joe O'Sullivan, Kevin Prise, David Hirst, Frederick Currell

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

Background and purpose: The addition of gold nanoparticles (GNPs) to tumours leads to an increase in dose due to their high density and energy absorption coefficient, making it a potential radiosensitiser. However, experiments have observed radiosensitisations significantly larger than the increase in dose alone, including at megavoltage energies where gold's relative energy absorption is lowest. This work investigates whether GNPs create dose inhomogeneities on a sub-cellular scale which combine with non-linear dose dependence of cell survival to be the source of radiosensitisation at megavoltage energies.
Original languageEnglish
Pages (from-to)412-416
Number of pages5
JournalRadiotherapy and Oncology
Volume100
Issue number3
DOIs
Publication statusPublished - Sep 2011

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Hematology

Fingerprint Dive into the research topics of 'Nanodosimetric effects of gold nanoparticles in megavoltage radiation therapy'. Together they form a unique fingerprint.

Cite this