Nanofibrous microspheres: a biomimetic platform for bone tissue regeneration

Nimeet Desai, Shreya Pande, Lalitkumar K. Vora*, Nagavendra Kommineni*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Downloads (Pure)


Bone, a fundamental constituent of the human body, is a vital scaffold for support, protection, and locomotion, underscoring its pivotal role in maintaining skeletal integrity and overall functionality. However, factors such as trauma, disease, or aging can compromise bone structure, necessitating effective strategies for regeneration. Traditional approaches often lack biomimetic environments conducive to efficient tissue repair. Nanofibrous microspheres (NFMS) present a promising biomimetic platform for bone regeneration by mimicking the native extracellular matrix architecture. Through optimized fabrication techniques and the incorporation of active biomolecular components, NFMS can precisely replicate the nanostructure and biochemical cues essential for osteogenesis promotion. Furthermore, NFMS exhibit versatile properties, including tunable morphology, mechanical strength, and controlled release kinetics, augmenting their suitability for tailored bone tissue engineering applications. NFMS enhance cell recruitment, attachment, and proliferation, while promoting osteogenic differentiation and mineralization, thereby accelerating bone healing. This review highlights the pivotal role of NFMS in bone tissue engineering, elucidating their design principles and key attributes. By examining recent preclinical applications, we assess their current clinical status and discuss critical considerations for potential clinical translation. This review offers crucial insights for researchers at the intersection of biomaterials and tissue engineering, highlighting developments in this expanding field.

Original languageEnglish
Pages (from-to)4270-4292
Number of pages23
JournalACS Applied Bio Materials
Issue number7
Early online date01 Jul 2024
Publication statusPublished - 15 Jul 2024


  • Biomimetic
  • Bone regeneration
  • Microspheres
  • Scaffold
  • Tissue engineering

Cite this