@inbook{92308d9dadfd4e1ca20c962eef292d01,
title = "Nanoparticles beyond the blood-brain barrier for glioblastoma",
abstract = "Glioblastoma (GBM) is an incurable highly malignant cancer of the central nervous system (CNS). GBM is a complex cancer, which involves multiple molecular pathways and genetic mutations that propagate tumor growth. To prolong tumor control and patient survival, novel therapeutic strategies are required. The blood-brain barrier (BBB) is the protective barrier of the CNS and acts to maintain the brain microenvironment. It is a highly organized structure that impedes the delivery of many therapeutic agents to the brain. The emerging strategies which have been developed to circumvent the BBB for effective GBM therapy are detailed in this chapter. Invasive and noninvasive methods which can temporarily disrupt the overall organization and normal structure of the BBB in order to promote the penetration of nanoparticles to the CNS are described along with an evaluation of the key delivery technologies.",
author = "Lynn Jena and Dunne, {Nicholas J.} and McCarthy, {Helen O.}",
year = "2021",
month = jun,
day = "28",
doi = "10.1016/B978-0-12-821567-8.00027-0",
language = "English",
series = "Cancer Sensitizing Agents for Chemotherapy",
publisher = "Elsevier Academic Press ",
pages = "707--747",
editor = "Ramasamy Paulmurugan and Massoud, {Tarik F.}",
booktitle = "Glioblastoma resistance to chemotherapy: molecular mechanisms and innovative reversal strategies",
}
